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Pigment Epithelium-Derived Factor Expression in Colorectal Cancer Patients
Karolinska Institute, Stockholm, Sweden.
Ryhov County Hospital, Jönköping, Sweden.
Ryhov County Hospital, Jönköping, Sweden.
Ryhov County Hospital, Jönköping, Sweden.
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2010 (English)In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 28, no 8, 872-877 p.Article in journal (Refereed) Published
Abstract [en]

Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis and has been proposed to be a tumor suppressor in a variety of tumors. Limited reports exist of PEDF in colorectal cancer (CRC). We noted a 55% lower plasma level (p less than .001) of PEDF in the CRC patient group (1.6 mu g/mL) than in of a healthy control group (3.6 mu g/mL). A single nucleotide polymorphism (rs1136287, Tgreater thanC) was screened. In the control group, the CC genotype showed 30% lower PEDF plasma levels compared with the TT genotype (p less than .01), whereas the CRC patients failed to show any association regarding these genotypes.

Place, publisher, year, edition, pages
Informa Healthcare, 2010. Vol. 28, no 8, 872-877 p.
Keyword [en]
Pigment epithelium-derived factor; Polymorphism; Protein expression; Colorectal cancer
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-100338DOI: 10.3109/07357901003735675ISI: 000282754600013PubMedID: 20504225OAI: diva2:661703
Available from: 2013-11-04 Created: 2013-11-04 Last updated: 2013-11-15Bibliographically approved

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Wågsäter, Dick
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