liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Fluid Therapy LiDCO Controlled Trial-Optimization of Volume Resuscitation of Extensively Burned Patients through Noninvasive Continuous Real-Time Hemodynamic Monitoring LiDCO
Charles University of Prague, Czech Republic .
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping.
Charles University of Prague, Czech Republic .
Charles University of Prague, Czech Republic .
Show others and affiliations
2013 (English)In: Journal of Burn Care & Research, ISSN 1559-047X, Vol. 34, no 5, 537-542 p.Article in journal (Refereed) Published
Abstract [en]

This pilot trial aims at gaining support for the optimization of acute burn resuscitation through noninvasive continuous real-time hemodynamic monitoring using arterial pulse contour analysis. A group of 21 burned patients meeting preliminary criteria (age range 18-75 years with second- third- degree burns and TBSA 10-75%) was randomized during 2010. A hemodynamic monitoring through lithium dilution cardiac output was used in 10 randomized patients (LiDCO group), whereas those without LiDCO monitoring were defined as the control group. The modified Brooke/Parkland formula as a starting resuscitative formula, balanced crystalloids as the initial solutions, urine output of 0.5ml/kg/hr as a crucial value of adequate intravascular filling were used in both groups. Additionally, the volume and vasopressor/inotropic support were based on dynamic preload parameters in the LiDCO group in the case of circulatory instability and oligouria. Statistical analysis was done using t-tests. Within the first 24 hours postburn, a significantly lower consumption of crystalloids was registered in LiDCO group (P = .04). The fluid balance under LiDCO control in combination with hourly diuresis contributed to reducing the cumulative fluid balance approximately by 10% compared with fluid management based on standard monitoring parameters. The amount of applied solutions in the LiDCO group got closer to Brooke formula whereas the urine output was at the same level in both groups (0.8ml/kg/hr). The new finding in this study is that when a fluid resuscitation is based on the arterial waveform analysis, the initial fluid volume provided was significantly lower than that delivered on the basis of physician-directed fluid resuscitation (by urine output and mean arterial pressure). (J Burn Care Res 2013;34:537-542)

Place, publisher, year, edition, pages
Lippincott, Williams and Wilkins , 2013. Vol. 34, no 5, 537-542 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-100496DOI: 10.1097/BCR.0b013e318278197eISI: 000325705700016OAI: diva2:662885

Funding Agencies|Grant Agency of the Ministry of Health of Czech Republic|IGA MZ CR: NS10014-4/2008|

Available from: 2013-11-08 Created: 2013-11-08 Last updated: 2014-03-24

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sjöberg, Folke
By organisation
Division of Clinical SciencesFaculty of Health SciencesDepartment of Hand and Plastic SurgeryDepartment of Anaesthesiology and Intensive Care in Linköping
In the same journal
Journal of Burn Care & Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 96 hits
ReferencesLink to record
Permanent link

Direct link