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Estrogenic influences in pain processing
Uppsala University, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.
2013 (English)In: Frontiers in neuroendocrinology (Print), ISSN 0091-3022, E-ISSN 1095-6808, Vol. 34, no 4, 329-349 p.Article, review/survey (Refereed) Published
Abstract [en]

Gonadal hormones not only play a pivotal role in reproductive behavior and sexual differentiation, they also contribute to thermoregulation, feeding, memory, neuronal survival, and the perception of somatosensory stimuli. Numerous studies on both animals and human subjects have also demonstrated the potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and they therefore need to be evaluated specifically to determine the localization and intrinsic characteristics of the neurons engaged. The aim of this review is to summarize the morphological as well as biochemical evidence in support for gonadal hormone modulation of nociceptive processing, with particular focus on estrogens and spinal cord mechanisms.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 34, no 4, 329-349 p.
Keyword [en]
Nociception, Gonadal hormones, Estrogens, Estrogen receptors, Spinal dorsal horn, Medullary dorsal horn, Steroid hormones, Enkephalin, Opioid, Pain mechanisms
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-100488DOI: 10.1016/j.yfrne.2013.06.001ISI: 000325737300007OAI: diva2:662955

Funding Agencies|Swedish Research Council|12X-07879|

Available from: 2013-11-08 Created: 2013-11-08 Last updated: 2014-11-19

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Blomqvist, Anders
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