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Low temperature synthesis of seed mediated CuO bundle of nanowires, their structural characterisation and cholesterol detection
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, The Institute of Technology.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.ORCID iD: 0000-0001-6235-7038
2013 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, Vol. 33, no 7, 3889-3898 p.Article in journal (Refereed) Published
Abstract [en]

In this study, we have successfully synthesised CuO bundle of nanowires using simple, cheap and low temperature hydrothermal growth method. The growth parameters such as precursor concentration and time for duration of growth were optimised. The field emission scanning electron microscopy (FESEM) has demonstrated that the CuO bundles of nanowires are highly dense, uniform and perpendicularly oriented to the substrate. The high resolution transmission electron microscopy (HRTEM) has demonstrated that the CuO nanostructures consist of bundle of nanowires and their growth pattern is along the [010] direction. The X-ray diffraction (XRD) technique described that CuO bundle of nanowires possess the monoclinic crystal phase. The surface and chemical composition analyses were carried out with X-ray photoelectron spectroscopy (XPS) technique and the obtained results suggested the pure crystal state of CuO nanostructures. In addition, the CuO nanowires were used for the cholesterol sensing application by immobilising the cholesterol oxidase through electrostatic attraction. The infrared reflection absorption spectroscopy study has also revealed that CuO nanostructures are consisting of only Cu-O bonding and has also shown the possible interaction of cholesterol oxidase with the sharp edge surface of CuO bundle of nanowires. The proposed cholesterol sensor has demonstrated the wide range of detection of cholesterol with good sensitivity of 33.88 +/- 0.96 mV/decade. Moreover, the CuO bundle of nanowires based sensor electrode has revealed good repeatability, reproducibility, stability, selectivity and a fast response time of less than 10 s. The cholesterol sensor based on the immobilised cholesterol oxidase has good potential applicability for the determination of cholesterol from the human serum and other biological samples.

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 33, no 7, 3889-3898 p.
Keyword [en]
CuO bundle of nanowires, Hydrothermal method, Seed layer, IRAS, Potentiometric technique, Cholesterol sensor
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-100485DOI: 10.1016/j.msec.2013.05.029ISI: 000325445700042OAI: diva2:662962
Available from: 2013-11-08 Created: 2013-11-08 Last updated: 2014-02-17
In thesis
1. Synthesis of metal oxide nanostructures, their characterization and chemical sensing applications
Open this publication in new window or tab >>Synthesis of metal oxide nanostructures, their characterization and chemical sensing applications
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The existence of nanomaterials is a revolutionizing step towards the fabrication of nanodevices and it enhances the enthusiasm of the researchers for the development of new devices with improved performance relative to that of bulk material based devices. Among the nanomaterials, the metal oxide nanostructures have drawn the attention of scientific community in the development of different biochemical and biomedical nanodevices in the recent time. Today, the nanotechnology based applications of several materials particularly biosensing, molecular imaging, biological separation, biomarkers and photodynamic therapy have given wide spectrum of the fabrication of novel and sensitive nanodevices. The attraction of nanomaterials based devices is hidden in the fact of their desirable and unique properties such as high surface to volume ratio, biocompatibility, fast electron transfer rate, and nontoxic in many cases. The biocompatibility is the most favourable property of several nanomaterials such as ZnO, TiO2 etc. which provide the solid platform for the synthesis of nanomedicine. In the sensor technology, the uses of nanomaterials have shown the drastic and bombastic realization of high sensitivity for a particular sensor and the possible detection of specific analytes from their small volumes. The metal oxide nanostructures show a fast electron communication, and high degree of adsorption of biosensitive material which further enhances the sensitivity of nanosensor device. The metal oxides nanostructures  exhibit tuneable size; morphology based chemical and physical properties which are easily to combine with biosensitive material in the fabrication of sensitive chemical and biosensors. The metal oxide nanostructures experienced attractive surface chemistry, high surface  to volume ratio, valuable thermal and electrical properties, therefore the development of nanosensors is accompanied by high sensitivity, low limit of detection and a fast response time.

In this dissertation, several metal oxide nanostructures have been presented such as ZnO, CuO, NiO, Co3O4, Fe2O3, Mn3O4, NiCo2O4 and TiO2. By exploiting the favourable properties of these metal oxides for the sensing, thus have been used potentially in the fabrication of chemical nanosensors.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2014. 56 p.
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1577
Hydrothermal method, seed layer, ZnO nanorods, ZnO nanotubes, immunosensor, iron ferrite, glucose sensor, well aligned ZnO nanorods, CuO nanoleaves, CuO nanosheets, CuO bundle of nanowires
National Category
Natural Sciences
urn:nbn:se:liu:diva-104422 (URN)978-91-7519-394-6 (print) (ISBN)
Public defence
2014-03-20, K 3, Kåkenhus, Campus Norrköping, Linköpings universitet, Norrköping, 10:00 (English)
Available from: 2014-02-17 Created: 2014-02-17 Last updated: 2014-02-17Bibliographically approved

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