liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A continuum model for excitation–contraction of smooth muscle under finite deformations
Linköping University, Department of Management and Engineering, Mechanics. Linköping University, The Institute of Technology.
Linköping University, Department of Management and Engineering, Mechanics. Linköping University, The Institute of Technology.
2014 (English)In: Journal of Theoretical Biology, ISSN 0022-5193, E-ISSN 1095-8541, Vol. 355, 1-9 p.Article in journal (Refereed) Published
Abstract [en]

The main focus in most of continuum based muscle models is the muscle contraction dynamics while other physiological processes governing muscle contraction, e.g., the cell membrane excitation and the activation, are ignored. These latter processes are essential to initiate contraction and to determine the amount of generated force, and by excluding them, the developed model cannot replicate the true behavior of the muscle in question. The aim of this study is to establish a thermodynamically and physiologically consistent framework which allows to model smooth muscle contraction by including cell membrane excitability and kinetics of myosin phosphorylation, along with dynamics of smooth muscle contraction. The model accounts for these processes through a set of coupled dissipative constitutive equations derived by applying the first principles. To show the performance of the derived model, it is evaluated for two different cases: a mechanochemical study of pig taenia coli cells where the excitation process is excluded, and a complete excitation–contraction process of rat myometrium. The results show that the model is able to replicate important aspects of the smooth muscle EC process acceptably.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 355, 1-9 p.
Keyword [en]
Smooth muscle excitation–contraction, Smooth muscle continuum model, The membrane model, Hodgkin-Huxley model, Hai-Murphy model
National Category
Other Mechanical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-100778DOI: 10.1016/j.jtbi.2014.03.016ISI: 000337865100001OAI: oai:DiVA.org:liu-100778DiVA: diva2:663554
Available from: 2013-11-12 Created: 2013-11-12 Last updated: 2017-12-06Bibliographically approved
In thesis
1. On the continuum muscle modeling
Open this publication in new window or tab >>On the continuum muscle modeling
2013 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Modeling muscle behavior using techniques developed in continuum mechanics is a growing eld of research. The developed models allow for a more generalized way of computing stresses and deformations, specially, when it comes to using nite element techniques. Current continuum muscle models mostly focus on the kinetics of the muscle contraction, while other fundamental physiological processes such as, the membrane excitation and the activation process are disregarded. These processes are essential to initiate the contraction, and to determine the amount of generated force, respectively. In this thesis, muscle modeling is carried out in a thermodynamically consistent framework where the physiological processes governing muscle contraction are included. The behavior of the muscle is described by dissipative constitutive equations derived from applying the principles of thermodynamics. The muscle model is then validated through comparing the model response to available experimental data.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2013. 21 p.
Series
Linköping Studies in Science and Technology. Thesis, ISSN 0280-7971 ; 1630
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-100781 (URN)LIU–TEK–LIC–2013:64 (Local ID)978-91-7519-468-4 (ISBN)LIU–TEK–LIC–2013:64 (Archive number)LIU–TEK–LIC–2013:64 (OAI)
Presentation
2013-12-13, A38, A-huset, Campus Valla, Linköpings universitet, Linköping, 13:15 (English)
Opponent
Supervisors
Available from: 2013-11-12 Created: 2013-11-12 Last updated: 2017-05-15Bibliographically approved
2. A Continuum Framework for Modeling the Excitation–Contraction Coupling of Smooth Muscle
Open this publication in new window or tab >>A Continuum Framework for Modeling the Excitation–Contraction Coupling of Smooth Muscle
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Excitation-contraction coupling of smooth muscle refers to a chain of coupled physiological processes which convert a stimulus to a mechanical response. These processes can be disassociated into ionic transport during cell membrane excitation, activation of myosin light chains, and muscle contraction caused by actin-myosin interaction (filament sliding). This thesis concerns the development of a framework which allows to model the smooth muscle excitation-contraction coupling constitutively by applying the principle of virtual power and dissipation inequality. In doing so, the transport of ions through membrane channels is characterized by an ionic flux and an ionic supply, both governed by an electrochemical potential energy. By letting the Helmholtz free energy to be dependent on the myosin light chain configurations during contraction, the myosin light chain activation process, i.e., myosin phosphorylation, is included. The activation process links the membrane excitation to the filament sliding. A contractile element is presented to replicate the active deformation caused by the filament sliding within the smooth muscle cell. This deformation is coupled to the overall deformation of the muscle tissue by assuming a distinct principal alignment for the contractile elements.

By employing this framework, an electro-chemo-mechanical model is derived by which the mechanical response of smooth muscle to an electrical stimulus is determined. This model is evaluated by comparing the model response to the experimental isometric stress data obtained from rat uterine smooth muscle tissue. By implementing this model in a finite element program, human uterine contractions during labor are simulated. This simulation determines important clinical factors, e.g., intrauterine pressure and provides the opportunity to investigate the effect of physiological and structural parameters on the uterine contractility.

Finally, a methodology to accommodate individualized parameters from intrauterine pressure measurements is established. This methodology allows to develop models with potentials of being used clinically to diagnose difficulties during labor and delivery.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2015. 39 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1687
National Category
Mechanical Engineering Applied Mechanics Materials Engineering
Identifiers
urn:nbn:se:liu:diva-121015 (URN)978-91-7519-020-4 (ISBN)
Public defence
2015-09-08, C3, Hus C, Campus Valla, Linköping, 10:15 (English)
Opponent
Supervisors
Available from: 2015-09-02 Created: 2015-09-02 Last updated: 2017-05-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Sharifimajd, BabakStålhand, Jonas

Search in DiVA

By author/editor
Sharifimajd, BabakStålhand, Jonas
By organisation
MechanicsThe Institute of Technology
In the same journal
Journal of Theoretical Biology
Other Mechanical Engineering

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 127 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf