A continuum model for excitation–contraction of smooth muscle under finite deformations
2014 (English)In: Journal of Theoretical Biology, ISSN 0022-5193, E-ISSN 1095-8541, Vol. 355, 1-9 p.Article in journal (Refereed) Published
The main focus in most of continuum based muscle models is the muscle contraction dynamics while other physiological processes governing muscle contraction, e.g., the cell membrane excitation and the activation, are ignored. These latter processes are essential to initiate contraction and to determine the amount of generated force, and by excluding them, the developed model cannot replicate the true behavior of the muscle in question. The aim of this study is to establish a thermodynamically and physiologically consistent framework which allows to model smooth muscle contraction by including cell membrane excitability and kinetics of myosin phosphorylation, along with dynamics of smooth muscle contraction. The model accounts for these processes through a set of coupled dissipative constitutive equations derived by applying the first principles. To show the performance of the derived model, it is evaluated for two different cases: a mechanochemical study of pig taenia coli cells where the excitation process is excluded, and a complete excitation–contraction process of rat myometrium. The results show that the model is able to replicate important aspects of the smooth muscle EC process acceptably.
Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 355, 1-9 p.
Smooth muscle excitation–contraction, Smooth muscle continuum model, The membrane model, Hodgkin-Huxley model, Hai-Murphy model
Other Mechanical Engineering
IdentifiersURN: urn:nbn:se:liu:diva-100778DOI: 10.1016/j.jtbi.2014.03.016ISI: 000337865100001OAI: oai:DiVA.org:liu-100778DiVA: diva2:663554