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Stem cells and enhanced healing of chronic tympanic membrane perforation
Karolinska Institute/Karolinska University Hospital, Stockholm, Sweden.
Karolinska Institute/Karolinska University Hospital, Stockholm, Sweden.
University of Antwerp, Groenenburgerlaan, Belgium .
Karolinska Institute/Karolinska University Hospital, Stockholm, Sweden.
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2008 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 128, no 4, 352-359 p.Article in journal (Refereed) Published
Abstract [en]

CONCLUSIONS:

Important information about the basic reparative process of tympanic membrane (TM) healing is shown, which can be incorporated for further clinical understanding. This provides a basis for the exploration of stem cell treatment for TM perforations and holds promise for future improvements.

OBJECTIVES:

This study aimed to analyse the healing of TM perforation by using stem cells and the stiffness of the membrane was tested in an acute and long-term study.

MATERIALS AND METHODS:

Sprague-Dawley rats were used in a model of TM perforation. The perforation was performed with a laser system. Stem cells were applied and the healing time and morphological analysis were performed with light and transmission electron microscope. Stiffness was examined by moiré interferometry.

RESULTS:

The stiffness of the perforated and healed TM was restored after just 2 weeks. In the chronic perforation model, mesenchymal stem cells enhanced the healing.

Place, publisher, year, edition, pages
Informa Healthcare, 2008. Vol. 128, no 4, 352-359 p.
Keyword [en]
tympanic membrane; laser myringotomy; healing; moire interferometry; stem cell
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-101022DOI: 10.1080/00016480701762508ISI: 000254394600003PubMedID: 18368564OAI: oai:DiVA.org:liu-101022DiVA: diva2:665052
Available from: 2013-11-18 Created: 2013-11-18 Last updated: 2017-12-06

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Olivius, Petri

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CiteExportLink to record
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Citation style
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  • Other style
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  • de-DE
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  • en-US
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  • nn-NB
  • sv-SE
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