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Imaging of the guinea pig cochlea following round window gadolinium application
Karolinska Institutet, Stockholm, Sweden.
Örebro University Hospital, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
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2004 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 15, no 12, 1927-1930 p.Article in journal (Refereed) Published
Abstract [en]

Precise, non-invasive determination of the aetiology and site of pathology of inner ear disorders is difficult. The aim of this study was to describe an alternative method for inner ear visualization, based on local application of the paramagnetic contrast agent gadolinium. Using a 4.7 T MRI scanner, high contrast images of all four cochlear turns were obtained 3.5 h after placing gadolinium on the round window membrane. Gadolinium cleared from the cochlea within 96 h. Auditory brainstem response measurements performed on a separate group of animals showed no significant threshold shifts after the application, indicating that gadolinium is non-toxic to the guinea pig cochlea.

Place, publisher, year, edition, pages
Wolters Kluwer, 2004. Vol. 15, no 12, 1927-1930 p.
Keyword [en]
Gadolinium, Guinea pig, Hearing, Inner ear, MRI, Round window membrane
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-101072PubMedID: 15305139OAI: oai:DiVA.org:liu-101072DiVA: diva2:665145
Available from: 2013-11-19 Created: 2013-11-19 Last updated: 2017-12-06Bibliographically approved

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Fridberger, Anders

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