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In vivo outer hair cell length changes expose the active process in the cochlea
Karolinska Institutet / Karolinska University Hospital, Stockholm, Sweden.
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2012 (English)In: PloS one, ISSN 1932-6203, Vol. 7, no 4, e32757- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Mammalian hearing is refined by amplification of the sound-evoked vibration of the cochlear partition. This amplification is at least partly due to forces produced by protein motors residing in the cylindrical body of the outer hair cell. To transmit power to the cochlear partition, it is required that the outer hair cells dynamically change their length, in addition to generating force. These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification.

METHODOLOGY/PRINCIPAL FINDINGS: Using in vivo optical coherence tomography, we demonstrate that outer hair cells in living guinea pigs have length changes with unexpected timing and magnitudes that depend on the stimulus level in the sensitive cochlea.

CONCLUSIONS/SIGNIFICANCE: The level-dependent length change is a necessary condition for directly validating that power is expended by the active process presumed to underlie normal hearing.

Place, publisher, year, edition, pages
2012. Vol. 7, no 4, e32757- p.
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-101052DOI: 10.1371/journal.pone.0032757PubMedID: 22496736OAI: oai:DiVA.org:liu-101052DiVA: diva2:665166
Available from: 2013-11-19 Created: 2013-11-19 Last updated: 2014-03-06

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Fridberger, Anders

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf