liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Sound-induced length changes in outer hair cell stereocilia
Karolinska Institutet / Karolinska University Hospital, Stockholm, Sweden.ORCID iD: 0000-0001-9615-3885
Karolinska Institutet / Karolinska University Hospital, Stockholm, Sweden.
2012 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 3Article in journal (Refereed) Published
Abstract [en]

Hearing relies on mechanical stimulation of stereocilia bundles on the sensory cells of the inner ear. When sound hits the ear, each stereocilium pivots about a neck-like taper near their base. More than three decades of research have established that sideways deflection of stereocilia is essential for converting mechanical stimuli into electrical signals. Here we show that mammalian outer hair cell stereocilia not only move sideways but also change length during sound stimulation. Currents that enter stereocilia through mechanically sensitive ion channels control the magnitude of both length changes and bundle deflections in a reciprocal manner: the smaller the length change, the larger is the bundle deflection. Thus, the transduction current is important for maintaining the resting mechanical properties of stereocilia. Hair cell stimulation is most effective when bundles are in a state that ensures minimal length change.

Place, publisher, year, edition, pages
2012. Vol. 3
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-101049DOI: 10.1038/ncomms2100PubMedID: 23033070OAI: oai:DiVA.org:liu-101049DiVA: diva2:665170
Available from: 2013-11-19 Created: 2013-11-19 Last updated: 2017-12-06

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Hakizimana, PierreFridberger, Anders

Search in DiVA

By author/editor
Hakizimana, PierreFridberger, Anders
In the same journal
Nature Communications
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 250 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf