Advances in the management of hereditary medullary thyroid cancer
2005 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 257, no 1, 50-59 p.Article in journal (Refereed) Published
This work draws on recent advances during the era of codon-oriented prophylactic surgery for hereditary medullary thyroid cancer (MTC). Milestones included identification of RET (REarranged during Transfection) as the susceptibility gene, introduction of prophylactic surgery on evidence of a RET germline mutation, revelation of genotype-phenotype correlations within the MEN 2 spectrum and demonstration of age-related progression of MTC. Novel surgical techniques, notably systemic microdissection and compartment-oriented surgery, have greatly enhanced surgical cure. Uncovering molecular pathways from RET genotype to MEN 2 phenotype should provide treatment options for RET mutation carriers whose MTC currently is too advanced for cure.
Place, publisher, year, edition, pages
Wiley-Blackwell, 2005. Vol. 257, no 1, 50-59 p.
age-related progression, calcitonin, monitoring, medullary thyroid cancer, MEN type 2, nodal metastasis, RET proto-oncogene.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-101411DOI: 10.1111/j.1365-2796.2004.01423.xPubMedID: 15606376OAI: oai:DiVA.org:liu-101411DiVA: diva2:666141