liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Detailed assessment of chromosome 22 aberrations in sporadic pheochromocytoma using array-CGH
Rudbeck Laboratory, Uppsala University, Sweden.
Rudbeck Laboratory, Uppsala University, Sweden.
Rudbeck Laboratory, Uppsala University, Sweden.
Rudbeck Laboratory, Uppsala University, Sweden.
Show others and affiliations
2006 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 118, no 5, 1159-1164 p.Article in journal (Refereed) Published
Abstract [en]

Pheochromocytoma is a predominantly sporadic neuroendocrine tumor derived from the adrenal medulla. Previous low resolution LOH and metaphase-CGH studies reported the loss of chromosomes 1p, 3q, 17p and 22q at various frequencies. However, the molecular mechanism(s) behind development of sporadic pheochromocytoma remains largely unknown. We have applied high-resolution tiling-path microarray-CGH with the primary aim to characterize copy number imbalances affecting chromosome 22 in 66 sporadic pheochromocytomas. We detected copy number alterations on 22q at a frequency of 44%. The predominant finding was monosomy 22 (30%), followed by terminal deletions in 8 samples (12%) and a single interstitial deletion. We further applied a chromosome 1 tiling-path array in 7 tumors with terminal deletions of 22q and found deletions of 1p in all cases. Our overall results suggest that at least 2 distinct regions on both 22q and 1p are important in the tumorigenesis of sporadic pheochromocytoma. A large proportion of pheochromocytomas also displayed indications of cellular heterogeneity. Our study is to our knowledge the first array-CGH study of sporadic pheochromocytoma. Future analysis of this tumor type should preferably be performed in the context of the entire human genome using genome-wide array-CGH, which is a superior methodological approach. Supplemental material for this article can be found on the International Journal of Cancer website at

Place, publisher, year, edition, pages
John Wiley & Sons, 2006. Vol. 118, no 5, 1159-1164 p.
Keyword [en]
genomic microarray; chromosome 1; PTCH2; deletions; amplifications; tiling-path array; tumor heterogeneity
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-101417DOI: 10.1002/ijc.21385PubMedID: 16161042OAI: diva2:666153
Available from: 2013-11-22 Created: 2013-11-22 Last updated: 2013-12-06Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Gimm, Oliver
In the same journal
International Journal of Cancer
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 28 hits
ReferencesLink to record
Permanent link

Direct link