liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Familial Aggregation of Pure Tone Hearing Thresholds in an Aging European Population
University Hospital of Antwerp and University of Antwerp, Belgium.
University of Antwerp, Belgium.
University Hospital of Antwerp, Belgium.
University Hospital of Antwerp, Belgium.
Show others and affiliations
2013 (English)In: Otology and Neurotology, ISSN 1531-7129, E-ISSN 1537-4505, Vol. 34, no 5, 838-844 p.Article in journal (Refereed) Published
Abstract [en]


To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated.


Multicenter survey in 8 European centers.


One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study.


We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies.


Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2013. Vol. 34, no 5, 838-844 p.
National Category
URN: urn:nbn:se:liu:diva-101453DOI: 10.1097/MAO.0b013e318288646aPubMedID: 23739559OAI: diva2:666348
Available from: 2013-11-22 Created: 2013-11-22 Last updated: 2013-12-18

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Mäki-Torkko, Elina
By organisation
Division of NeuroscienceFaculty of Health SciencesDepartment of Otorhinolaryngology in Linköping
In the same journal
Otology and Neurotology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 113 hits
ReferencesLink to record
Permanent link

Direct link