liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Biomaterials for Enhancing Corneas and Spinal Cord Regeneration
University of Ottawa Eye Institute, Canada.
University of Ottawa, Canada.
University of Ottawa, Canada.
University of Ottawa Eye Institute, Ontario, Canada.ORCID iD: 0000-0001-6024-4144
Show others and affiliations
2009 (English)In: Stem Cells: Basics and Applications / [ed] K.D. Deb, S.M. Totey and Tata McGraw Hill, McGraw-Hill, 2009Chapter in book (Other academic)
Abstract [en]

Repairing damaged or diseased tissues or organs to prevent failure using natural or bioengineered materials, is the essence of regenerative medicine. Technologies can involve the use of stem cells, gene therapy, tissue engineering, and the use of artificial organs. To date, researchers have been recreating a range of tissues and organs in vitro, with varying degrees of success. The tools to create scaffolds and structures are limited, and fine control over mechanical and environmental variables is complex. Also, there is a limited means of diagnosing at the molecular, cellular, and tissue levels what is actually happening within the constructs. In this review, we focus on efforts employed to build in vitro models of the nervous system, in particular, the peripheral nervous system and the related visual system. We examine the development of novel  biomaterials that serve as the building blocks for the fabrication of scaffolds in engineered tissues.

Scaffolds must be fabricated from biologically compatible materials to be used as cellular supports for an engineered tissue or organ. Cells must be able to proliferate and differentiate into the appropriate target tissue or organ, when a chosen 3D scaffold is used. Engineered tissues need to mimic morphological, physiological and biochemical properties of the natural tissue as closely as possible. Thus, construction requirements are rigorous and demanding. The cornea and peripheral nervous system (PNS) are currently experiencing advances in tissue engineering efforts, for both transplantation and in vitro testing.

Place, publisher, year, edition, pages
McGraw-Hill, 2009.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-101488ISBN: 978-0-07-015271-1OAI: diva2:666395
Available from: 2013-11-22 Created: 2013-11-22 Last updated: 2014-10-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Find book in another country/Hitta boken i ett annat land

Search in DiVA

By author/editor
Rafat, MehrdadFriffith, May
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 159 hits
ReferencesLink to record
Permanent link

Direct link