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Development of a Highly Elastic Bioengineered Cornea: From Research to Commercialization
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0001-6024-4144
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
2013 (English)Conference paper, Oral presentation with published abstract (Other academic)
Abstract [en]

Background: Despite the promising clinical results that we previously reported on biosynthetic corneas, more elastic materials are required for surgical manipulation and withstanding the adverse host conditions faced by high risk corneal transplants.

Purpose: The overall objective was to develop novel bioengineered materials that can replace the damaged corneal tissue. Another objective was to evaluate the in vivo integration of the materials in rabbit models using a femtosecond laser intrastromal surgical technique.

Methods: Bioengineered corneas were prepared using porcine collagen cross-linked by carbodiimides at various compositions and pH. Promising formulations were tested for their mechanical, optical, and enzymatic and thermal degradation properties as well as for interactions with corneal cells, and in vivo implantation in rabbit’s eyes. A femtosecond laser was used to cut 100 mircon thick discs of mid-stromal tissue from corneas of 15 rabbits and replaced with the bioengineered materials.

Results: The new material demonstrated improved mechanical properties while maintaining its clarity and biocompatibility. The bioengineered implant retained its shape, thickness, and clarity 8 weeks post-surgery in rabbits.  

Conclusions: The bioengineered cornea developed in this work has the potential to be used and commercialized as corneal implants to replace the damaged tissue or for corrective surgery applications.

Place, publisher, year, edition, pages
2013.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-101524OAI: oai:DiVA.org:liu-101524DiVA: diva2:666450
Conference
2nd Biotechnology World Conference, February 18-21 2013, Dubai, UAE
Available from: 2013-11-22 Created: 2013-11-22 Last updated: 2014-10-08Bibliographically approved

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Rafat, MehrdadLagali, NeilKoulikovska, MarinaFagerholm, Per

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Rafat, MehrdadLagali, NeilKoulikovska, MarinaFagerholm, Per
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Division of Cell BiologyFaculty of Health SciencesDivision of NeuroscienceDepartment of Ophthalmology in Linköping
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