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Monocyte Chemoattractant Protein 1 is a Prognostic Marker in ANCA-Associated Small Vessel Vasculitis
Department of Nephrology, Lund University Hospital, Institute for Clinical Sciences, Lund, Sweden and Kidney Research Laboratory, BMC C14, Lund, Sweden.
Department of Nephrology, Lund University Hospital, Institute for Clinical Sciences, Lund, Sweden.
Department of Nephrology, Lund University Hospital, Institute for Clinical Sciences, Lund, Sweden.
Department of Nephrology, Lund University Hospital, Institute for Clinical Sciences, Lund, Sweden.
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2009 (English)In: Mediators of Inflammation, ISSN 0962-9351, E-ISSN 1466-1861, Vol. 2009, no (2009), Art.-ID 584916- p.Article in journal (Refereed) Published
Abstract [en]

Background

The (anti neutrophil cytoplasmatic autoantibody ANCA), associated small vessel vasculitides (ASVV) are relapsing-remitting inflammatory disorders, involving various organs, such as the kidneys. (Monocyte chemoattractant protein 1 MCP-1) has been shown to be locally up regulated in glomerulonephritis and recent studies have pointed out MCP-1 as a promising marker of renal inflammation. Here we measure urinary cytokine levels in different phases of disease, exploring the possible prognostic value of MCP-1, together with (interleukin 6 IL-6), (interleukin 8 IL-8) and (immunoglobulin M IgM).

Methods

MCP-1, IL-6 and IL-8 were measured using commercially available ELISA kits, whereas IgM in the urine was measured by an in-house ELISA.

Results

The MCP-1 levels in urine were significantly higher in patients in stable phase of the disease, compared with healthy controls. Patients in stable phase, with subsequent adverse events; had significantly higher MCP-1 values than patients who did not. MCP-1 and IgM both tended to be higher in patients relapsing within three months, an observation, however, not reaching statistical significance. Urinary levels of IL-6 correlated with relapse tendency, and IL-8 was associated with disease outcome.

Conclusions

Patients with ASVV have raised cytokine levels in the urine compared to healthy controls, even during remission. Raised MCP-1 levels are associated with poor prognosis and possibly also with relapse tendency. The association with poor prognosis was stronger for U-MCP-1 than for conventional markers of disease like CRP, BVAS, and ANCA, as well as compared to candidate markers like U-IgM and U-IL-8. We thus consider U-MCP-1 to have promising potential as a prognostic marker in ASVV.

Place, publisher, year, edition, pages
New York, NY, USA: Hindawi Publishing Corporation, 2009. Vol. 2009, no (2009), Art.-ID 584916- p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-101574DOI: 10.1155/2009/584916ISI: 000268135800001OAI: oai:DiVA.org:liu-101574DiVA: diva2:666535
Available from: 2013-11-22 Created: 2013-11-22 Last updated: 2017-12-06Bibliographically approved

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Segelmark, Mårten

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