NPY in alcoholism and psychiatric disorders
2006 (English)In: NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics / [ed] Zofia Zukowska, Giora Z. Feuerstein, Basel: Birkhäuser Verlag, 2006, Vol. 95, 183-192 p.Chapter in book (Refereed)
The NPY system may well be one of the most interesting target systems for development of treatments for alcohol dependence as well as mood disorders such as depression and anxiety syndromes. NPY is an endogenous anxiolytic compound, functions as an antidepressant, and is effective in modifying alcohol intake in high drinking states. Through receptor subtype specific compounds, the NPY system offers an interesting and innovative future approach for treatment designs. Selective Y2 receptor antagonists and/or Y1 agonists that are peripherally available and effectively penetrate the CNS are possible candidates. In conclusion, the NPY system offers attractive targets for development of future treatments for depression, anxiety, and alcohol dependence.
Place, publisher, year, edition, pages
Basel: Birkhäuser Verlag, 2006. Vol. 95, 183-192 p.
, Experientia Supplementum, ISSN 1023-294X ; 95
IdentifiersURN: urn:nbn:se:liu:diva-101860DOI: 10.1007/3-7643-7417-9_14PubMedID: 16383007ISBN: 978-3-7643-7155-5 (print)ISBN: 978-3-7643-7417-4 (online)OAI: oai:DiVA.org:liu-101860DiVA: diva2:666712