liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Early post-natal exposure to low dose oral di(2ethylhexyl) phthalate affects the peripheral LH-concentration in plasma, but does not affect mating behavior in the post-pubertal boar
Swedish University of Agriculture Science, Sweden; .
Swedish University of Agriculture Science, Sweden; .
Swedish University of Agriculture Science, Sweden; .
Swedish University of Agriculture Science, Sweden; .
Show others and affiliations
2006 (English)In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 21, no 2, 160-166 p.Article in journal (Refereed) Published
Abstract [en]

In a split-litter design experiment, boars were exposed orally three times weekly to 300 mg/kg of di(2-ethylhexyl) phthalate (DEHP) between 3 and 7 weeks of age. Post-puberty, i.e. at 6 months of age the effects on endocrinology and mating behavior were examined. The response to stimulation with a synthetic GnRH-analogue at 9 months of age resulted initially in lower concentration of LH in the exposed animals, compared to the control animals. We did not find any effects of DEHP on the mating behavior. Also, the effects of DEHP during the treatment period on the plasma concentrations of testosterone, oestradiol and LH were examined. During the exposure period there was a transient decrease in plasma concentrations of LH in the control group, which did not occur in the boars exposed to DEHR The data suggest that DEHP in low repeated oral doses causes lasting effects on the hypothalamus-pituitary-gonadal axis. (c) 2005 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
Elsevier , 2006. Vol. 21, no 2, 160-166 p.
Keyword [en]
endocrine disruption; DEHP; male; domestic pig; mating; behavior; testosterone; LH
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-101807DOI: 10.1016/j.reprotox.2005.07.012ISI: 000235120600004OAI: diva2:666808
Available from: 2013-11-24 Created: 2013-11-22 Last updated: 2015-03-12

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Rodriguez-Martinez, Heriberto
In the same journal
Reproductive Toxicology
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 50 hits
ReferencesLink to record
Permanent link

Direct link