Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity
2013 (English)In: Cell Metabolism, ISSN 1550-4131, Vol. 18, no 4, 478-489 p.Article, review/survey (Refereed) Published
White and brown adipose tissues are hypervascularized and the adipose vasculature displays phenotypic and functional plasticity to coordinate with metabolic demands of adipocytes. Blood vessels not only supply nutrients and oxygen to nourish adipocytes, they also serve as a cellular reservoir to provide adipose precursor and stem cells that control adipose tissue mass and function. Multiple signaling molecules modulate the complex interplay between the vascular system and the adipocytes. Understanding fundamental mechanisms by which angiogenesis and vasculatures modulate adipocyte functions may provide new therapeutic options for treatment of obesity and metabolic disorders by targeting the adipose vasculature.
Place, publisher, year, edition, pages
CELL PRESS, 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA , 2013. Vol. 18, no 4, 478-489 p.
IdentifiersURN: urn:nbn:se:liu:diva-102088DOI: 10.1016/j.cmet.2013.08.008ISI: 000326267700007OAI: oai:DiVA.org:liu-102088DiVA: diva2:668930
Funding Agencies|Swedish Research Council||Swedish Cancer Foundation||Karolinska Institute Foundation||Karolinska Institute||Torsten Soderbergs Foundation||European Union Integrated Project of Metoxia|222741|European Research Council (ERC)|250021|2013-12-022013-11-292013-12-02