liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Transthyretin Is Dysregulated in Preeclampsia, and Its Native Form Prevents the Onset of Disease in a Preclinical Mouse Model
Brown University, RI USA .
University of Jena, Germany .
Brown University, RI USA .
Brown University, RI USA .
Show others and affiliations
2013 (English)In: American Journal of Pathology, ISSN 0002-9440, E-ISSN 1525-2191, Vol. 183, no 5, 1425-1436 p.Article in journal (Refereed) Published
Abstract [en]

Preeclampsia is a major pregnancy complication with potential short- and long-term consequences for both mother and fetus. Understanding its pathogenesis and causative biomarkers is likely to yield insights for prediction and treatment. Herein, we provide evidence that transthyretin, a transporter of thyroxine and retinal, is aggregated in preeclampsia and is present at reduced levels in sera of preeclamptic women, as detected by proteomic screen. We demonstrate that transthyretin aggregates form deposits in preeclampsia placental tissue and cause apoptosis. By using in vitro approaches and a humanized mouse model, we provide evidence for a causal link between dysregulated transthyretin and preeclampsia. Native transthyretin inhibits all preeclampsia-like features in the humanized mouse model, including new-onset proteinuria, increased blood pressure, glomerular endotheliosis, and production of anti-angiogenic factors. Our findings suggest that a focus on transthyretin structure and function is a novel strategy to understand and combat preeclampsia.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA , 2013. Vol. 183, no 5, 1425-1436 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-102082DOI: 10.1016/j.ajpath.2013.07.022ISI: 000326553400010OAI: diva2:668947

Funding Agencies|NIH|P20RR018728|National Institute of Environmental Health Sciences|P42ES013660|Rhode Island Research Alliance Collaborative Research Award|2009-28|

Available from: 2013-12-02 Created: 2013-11-29 Last updated: 2014-08-26

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Berg, Goran
By organisation
Division of Clinical SciencesFaculty of Health SciencesDepartment of Gynaecology and Obstetrics in Linköping
In the same journal
American Journal of Pathology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 28 hits
ReferencesLink to record
Permanent link

Direct link