liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Decreased circulatory response to hypovolemic stress in young women with type 1 diabetes
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Cardiology in Linköping.
Östergötlands Läns Landsting, Heart and Medicine Center, Department of Endocrinology. Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.ORCID iD: 0000-0002-9095-403X
2013 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 36, no 12, 4076-4082 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE:

Diabetes is associated with hemodynamic instability during different situations involving acute circulatory stress in daily life. Young men with type 1 diabetes have been shown to have impaired circulatory response to hypovolemic stress. The effect of type 1 diabetes on cardiovascular response to hypovolemia in young women is unknown, however.

RESEARCH DESIGN AND METHODS:

Lower body negative pressure of 30 cm H2O was used to create rapid hypovolemic stress in 15 young women with type 1 diabetes (DW) and 16 healthy women (control subjects [C]). Compensatory mobilization of venous capacitance blood (capacitance response) and net fluid absorption from tissue to blood were measured with a volumetric technique. Overall cardiovascular responses and plasma norepinephrine levels were measured.

RESULTS:

Capacitance response was reduced (DW, 0.67 ± 0.05; C, 0.92 ± 0.06) and developed slower in DW (P < 0.01). Capacitance response was further reduced with increasing levels of HbA1c. Fluid absorption was almost halved in DW (P < 0.01). The initial vasoconstrictor response was reduced and developed slower in DW (P < 0.05). Arterial vasoconstriction was further reduced in the presence of microvascular complications (P < 0.05).

CONCLUSIONS:

DW present with decreased and slower mobilization of venous capacitance blood and decreased net fluid absorption from tissue to blood during hypovolemic circulatory stress. Collectively, this indicates that DW are prone to hemodynamic instability, especially in the presence of microvascular complications and poor glycemic control.

Place, publisher, year, edition, pages
American Diabetes Association , 2013. Vol. 36, no 12, 4076-4082 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-102324DOI: 10.2337/dc13-0468ISI: 000327211500060PubMedID: 24130342OAI: oai:DiVA.org:liu-102324DiVA: diva2:676377
Note

Funding Agencies|Department of Medical and Health Sciences, Linkoping University||Futurum-the Academy of Health Care, Jonkoping County Council||Medical Research Council|12661|Swedish Heart and Lung Foundation||

Available from: 2013-12-05 Created: 2013-12-05 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

fulltext(912 kB)76 downloads
File information
File name FULLTEXT01.pdfFile size 912 kBChecksum SHA-512
9d30a357ae0e1eaa9ac1f3d2def3f5bb21b16b427cfdaa6fced54c0afbd5dfdd6b4d57cea6ff584ac3bb92f67b5aa0c5e4b4e41ad6b00f6fe390f29b21a4b6bb
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Lindenberger, MarcusLindström, TorbjörnLänne, Toste

Search in DiVA

By author/editor
Lindenberger, MarcusLindström, TorbjörnLänne, Toste
By organisation
Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Cardiology in LinköpingDepartment of EndocrinologyDepartment of Thoracic and Vascular Surgery
In the same journal
Diabetes Care
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 76 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 141 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf