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Regulation of thalamocortical axon branching by BDNF and synaptic vesicle cycling
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences. Osaka University, Suita, Japan.
Osaka University, Suita, Japan.
Osaka University, Suita, Japan.
Osaka University, Suita, Japan.
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2013 (English)In: Frontiers in Neural Circuits, ISSN 1662-5110, E-ISSN 1662-5110, Vol. 7, no 202Article in journal (Refereed) Published
Abstract [en]

During development, axons form branches in response to extracellular molecules. Little is known about the underlying molecular mechanisms. Here, we investigate how neurotrophin-induced axon branching is related to synaptic vesicle cycling for thalamocortical axons. The exogenous application of brain-derived neurotrophic factor (BDNF) markedly increased axon branching in thalamocortical co-cultures, while removal of endogenous BDNF reduced branching. Over-expression of a C-terminal fragment of AP180 that inhibits clathrin-mediated endocytosis affected the laminar distribution and the number of branch points. A dominant-negative synaptotagmin mutant that selectively targets synaptic vesicle cycling, strongly suppressed axon branching. Moreover, axons expressing the mutant synaptotagmin were resistant to the branch-promoting effect of BDNF. These results suggest that synaptic vesicle cycling might regulate BDNF induced branching during the development of the axonal arbor.

Place, publisher, year, edition, pages
2013. Vol. 7, no 202
Keyword [en]
Neocortex, development, BDNF, neurotrophin, axon branching, endocytosis, exocytosis, neurotransmitter release, synapse
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-102341DOI: 10.3389/fncir.2013.00202ISI: 000328755400001OAI: oai:DiVA.org:liu-102341DiVA: diva2:676711
Funder
Swedish Research Council, 2008-3050Swedish Research Council, 2008-2862
Available from: 2013-12-06 Created: 2013-12-06 Last updated: 2017-12-06

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Granseth, Björn

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