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Thirst response to acute hypovolaemia in healthy women and women prone to vasovagal syncope
Linköping University, Department of Social and Welfare Studies, Division of Health, Activity and Care. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping. Sodertalje Sjukhus, Sweden .
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences.
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2013 (English)In: Physiology and Behavior, ISSN 0031-9384, E-ISSN 1873-507X, Vol. 120, 34-39 p.Article in journal (Refereed) Published
Abstract [en]

The present study measured self-perceived thirst and plasma angiotensin II (ATII) concentrations during graded hypovolaemic stress, induced by lower body negative pressure (LBNP), to elucidate the dependence of thirst on haemodynamics. A total of 24 women aged between 20 and 36 (mean age, 23) years rated their thirst on a visual analogue scale, graded from 0 to 100, when LBNP of 20,30 and 40 mm Hg was applied. Half of the women had a history of vasovagal syncope (VVS). The results showed that the thirst score increased three-fold when LBNP was applied, from 11 (median; 25th-75th percentiles, 9-25) to 34 (27-53; P andlt; 0.001). The women in the VVS group had twice as great an increase as those without a history of VVS (P andlt; 0.02). The plasma ATII concentration increased significantly in response to LBNP, both in the VVS group and in the control group, but the changes did not correlate with thirst. Application of LBNP decreased systolic and mean arterial pressures, cardiac output and pulse pressure (P andlt; 0.001 for all), but thirst correlated only with increase in heart rate and, independently, with reduction of mean arterial pressure. In conclusion, thirst and ATII increase in response to hypovolaemic stress, but are not statistically related. The haemodynamic parameter that was most strongly related to thirst was tachycardia.

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 120, 34-39 p.
Keyword [en]
Thirst, Angiotensin II, Hypovolaemia, Stress, LBNP
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-102410DOI: 10.1016/j.physbeh.2013.06.019ISI: 000326553000005OAI: oai:DiVA.org:liu-102410DiVA: diva2:677349
Note

Funding Agencies|Sodertalje Sjukhus AB, Stockholm County Council||Futurum - the Academy of Health Care||Jonkoping County Council||Medical Research Council of Southeast Sweden||

Available from: 2013-12-09 Created: 2013-12-09 Last updated: 2017-12-06

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Hahn, Robert G.Engvall, JanSkoog, JohanLindenberger, Marcus

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Hahn, Robert G.Engvall, JanSkoog, JohanLindenberger, Marcus
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Division of Health, Activity and CareFaculty of Health SciencesDivision of Drug ResearchDepartment of Anaesthesiology and Intensive Care in LinköpingDivision of Cardiovascular MedicineDepartment of Clinical Physiology in LinköpingDepartment of Medical and Health SciencesDepartment of Cardiology in Linköping
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