Gold Nanostructures and their Applications in Diagnosis and Therapy of Cancer
2012 (English)In: Nanotechnology: diagnosis and treatment of cancers / [ed] Rinti Banerjee, New Delhi, India: Narosa Publishing House, 2012, 27-35 p.Chapter in book (Other academic) [Artistic work]
The molecular level scenario of cancer is recently rescaled from interactive molecular interaction maps to network representation and dynamic modeling (Stromback et al.**). The rescaling is primarily motivated by a systems biology approach (Gitenkunst et al 2007; Pribyl**). The future of nanoparticle based biological research perhaps lies in such systems based picture of interaction of nanoparticles with cells and their different compartments.
At present there are two distinct directions in which one finds prospects of nanoparticle based research in biology. Development of novel nano-probes used either for imaging or for therapeutic purpose and each of these perspectives are intricately related to the signaling networks existing in cancerous or normal cells (Irish et al., 2006). The nanotechnology approach can enable controlled perturbation in cell and intercellular compartments. In addition this will enable, efficient extraction of image based information of the cellular and sub cellular function, and design of drugs particularly in cases in which the targeted delivery is intended (Hu et al., 2007).
Thus, nanotechnology based approaches are fast emerging as efficient aids to in vitro diagnostic techniques and to therapeutic procedures. The focus of this chapter is to concentrate on approaches in nanotechnology based diagnosis. This would be followed up by some discussions on formulation of nano-therapeutic strategy where specialized issues like toxicity and their significance would be touched-upon (Yadav et al, 2009). The hypotheses with which the nanotechnology is applied in cancer research are (a) Early stage detection is very difficult due to less phenotypic expressions. (b) Most of the anticancer drugs cannot differentiate greatly between normal and cancerous cells. While the first point is pivotal in the diagnostic approaches, the second aspect is more relevant with respect to nano-based therapeutic procedures.
Advanced technologies for tumor imaging, early detection, new methods for accurate diagnosis and prognosis are components of the former. The second issue, namely the targeted therapy has been subject of keen interest to a large section of researchers. Introduction of processes like laser or superficial X-ray irradiation in which nanoparticles may cause targeted and specific killing is an encouraging aspect of its use. Safety issues of nanoparticle-based drugs, their biodegradation or exclusion are the issues that have to develop side by side so as to make nano drugs acceptable in medicine. Other than this, special progresses in the treating aggressive and lethal cancers such as bone metastasis and development of nanomaterials that can be accessible to brain and other inaccessible tissues are some of the additional aspects that need a detailed consideration. A third equally important perspective exists for nanoparticle based sensing. This aspect is especially important for plasmonic nanoparticles like gold colloids.
Place, publisher, year, edition, pages
New Delhi, India: Narosa Publishing House, 2012. 27-35 p.
Cancer, Nanotechnology, Diagnostics, Drug Delivery
IdentifiersURN: urn:nbn:se:liu:diva-102428ISBN: 978-81-8487-159-3OAI: oai:DiVA.org:liu-102428DiVA: diva2:677567