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Reduced intensity-conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation: a study by the European Group for Blood and Marrow Transplantation
University of London Imperial Coll Science Technology and Med, England .
University of London Imperial Coll Science Technology and Med, England .
Leiden University, Netherlands .
University of Roma Tor Vergata, Italy .
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2013 (English)In: Bone Marrow Transplantation, ISSN 0268-3369, E-ISSN 1476-5365, Vol. 48, no 11, 1395-1400 p.Article in journal (Refereed) Published
Abstract [en]

Outcomes and prognostic factors of reduced intensity-conditioned allo-SCT (RIC allo-SCT) for multiple myeloma (MM) relapsing or progressing after prior autologous (auto)-SCT are not well defined. We performed an analysis of 413 MM patients who received a related or unrelated RIC allo-SCT for the treatment of relapse/progression after prior auto-SCT. Median age at RIC allo-SCT was 54.1 years, and 44.6% of patients had undergone two or more prior auto-SCTs. Median OS and PFS from the time of RIC allo-SCT for the entire population were 24.7 and 9.6 months, respectively. Cumulative non-relapse mortality (NRM) at 1 year was 21.5%. In multivariate analysis, CMV seronegativity of both patient and donor was associated with significantly better PFS, OS and NRM. Patient-donor gender mismatch was associated with better PFS, fewer than two prior auto-SCT was associated with better OS, and shorter time from the first auto-SCT to the RIC allo-SCT was associated with lower NRM. The results of this study identify patient and donor CMV seronegativity as the key prognostic factor for outcome after RIC allo-SCT for MM relapsing or progressing after prior auto-SCT.

Place, publisher, year, edition, pages
Nature Publishing Group: Open Access Hybrid Model Option B , 2013. Vol. 48, no 11, 1395-1400 p.
Keyword [en]
myeloma, allogeneic, stem cell transplantation, reduced-intensity
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-102500DOI: 10.1038/bmt.2013.73ISI: 000326887900005OAI: oai:DiVA.org:liu-102500DiVA: diva2:678593
Available from: 2013-12-12 Created: 2013-12-12 Last updated: 2017-12-06

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Ahlberg, Lucia

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