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Insulin sensitivity and beta-cell function after carbohydrate oral loading in hip replacement surgery: A double-blind, randomised controlled clinical trial
Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping. Södertälje Hospital, Sweden.
Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
2014 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 33, no 3, 392-398 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND & AIMS: Surgery initiates a series of physiological stress processes in the body, inducing transient insulin resistance. Preoperative carbohydrate treatment can reduce the latter phenomenon. We investigated the effects of carbohydrate loading on insulin sensitivity and beta-cell function after elective hip replacement.

METHODS: Twenty-three nondiabetic patients (mean age of 68 years) who underwent elective hip replacement surgery participated in this double-blind controlled study. The patients were randomised to a nutrition group, which ingested a carbohydrate-rich fluid (50 kcal/100 ml) (Preop(®)), or a control group (tap water flavoured with lemon) 800 ml + 400 ml before the surgery. The insulin response (beta-cell function) and the insulin sensitivity were measured with an intravenous glucose tolerance test (IVGTT) and a hyperinsulinaemic euglycaemic glucose clamp, respectively, one day before and two days after the surgery.

RESULTS: Insulin sensitivity decreased by 51% (median; 25-75th percentiles 35-61) after ingesting Preop(®) and by 39% (21-51) after ingesting in the control group (n.s.). The postoperative IVGTT in the nutrition group was followed by a significantly larger area under the curve (AUC) for plasma insulin (+54% versus the preoperative IVGTT) compared to the control group (+7%). This difference was already apparent during the first phase (0-10 min) of insulin secretion (+20 and -21%, respectively; P < 0.05).

CONCLUSIONS: The patients randomised to the carbohydrate oral fluid or the water prior to the surgery demonstrated a significant but similar decrease in insulin sensitivity. The carbohydrates increased the beta-cell function as a compensatory response to the disposition index, resulting in a smaller reduction in surgery-induced insulin resistance compared to the tap water. The study was registered at (NCT01774084).

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 33, no 3, 392-398 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-102529DOI: 10.1016/j.elnu.2013.08.003ISI: 000336711200003PubMedID: 24007934ScopusID: 2-s2.0-84899631491OAI: diva2:678849
Available from: 2013-12-13 Created: 2013-12-13 Last updated: 2015-04-08

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Hahn, Robert G
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Division of Drug ResearchFaculty of Health SciencesDepartment of Anaesthesiology and Intensive Care in Linköping
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