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IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs
Panum Institute, University of Copenhagen, Denmark.
Panum Institute, University of Copenhagen, Denmark.
Panum Institute, University of Copenhagen, Denmark.
Panum Institute, University of Copenhagen, Denmark.
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2007 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 104, no 39, 15364-15369 p.Article in journal (Refereed) Published
Abstract [en]

Successful therapeutic angiogenesis for the treatment of ischemic disorders relies on selection of optimal proangiogenic or arteriogenic agents that are able to promote establishment of functional collateral networks. Here, we show that IL-20, a pleiotropic inflammatory cytokine, displays an imperative effect on vascular remodeling. Stimulation of both large and microvascular endothelial cells with IL-20 leads to activation of receptor-dependent multiple intracellular signaling components, including increased phosphorylation levels of JAK2/STAT5, Erk1/2, and Akt; activation of small GTP-binding proteins Rac and Rho; and intracellular release of calcium. Surprisingly, IL-20 significantly promotes endothelial cell tube formation without affecting their proliferation and motility. These findings suggest that the vascular function of IL-20 involves endothelial cell organization, vessel maturation, and remodeling. Consistent with this notion, delivery of IL-20 to the ischemic muscle tissue significantly improves arteriogenesis and blood perfusion in a rat hind-limb model. Our findings provide mechanistic insights on vascular functions of IL-20 and define therapeutic implication of this cytokine for the treatment of ischemic disorders.

Place, publisher, year, edition, pages
National Academy of Sciences , 2007. Vol. 104, no 39, 15364-15369 p.
Keyword [en]
arteriogenesis; collateral growth; therapeutical angiogenesis; ischemia
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-102669DOI: 10.1073/pnas.0707302104PubMedID: 17878297OAI: oai:DiVA.org:liu-102669DiVA: diva2:680750
Available from: 2013-12-18 Created: 2013-12-18 Last updated: 2017-12-06Bibliographically approved

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Wahlberg, Eric

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf