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Determining optimal noninvasive parameters for the prediction of left ventricular remodeling in chronic ischemic patients
University Hospital Leuven, Belgium .
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Oslo University Hospital, Norway .
Kings College Hospital London, England .
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2013 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, Vol. 47, no 6, 329-334 p.Article in journal (Refereed) Published
Abstract [en]

Objectives. DOPPLER-CIP aims to determine the optimal noninvasive parameters (myocardial function, perfusion, ventricular blood flow, cell integrity) and methodology (ergometry, echocardiography, scintigraphy, MRI) in a given ischemic substrate that best predicts the impact of an intervention (or the lack thereof) on adverse morphological ventricular remodeling and functional recovery. Moreover, the relative predictive value of each of these parameters, in respect to the cost of extracting this information in order to enable optimization of cost-effectiveness for improved health care, will be determined by this project. Design. DOPPLER-CIP is a multi-center registry study. All patients with ischemic heart disease included in this study undergo at least two noninvasive stress imaging examinations at baseline. The presence/or absence of left ventricular (LV) remodeling will be assessed after a follow-up of 2 years, during which all cardiac events will be registered. Results. 676 patients were included. Currently, baseline data analysis is almost finished and the follow-up is ongoing. Conclusions. After completion, DOPPLER-CIP will provide evidence-based guidelines toward the most effective use of cardiac imaging in the chronically ischemic heart disease patient. The study will generate information, knowledge, and insight into the new imaging methodologies and into the pathophysiology of chronic ischemic heart disease.

Place, publisher, year, edition, pages
Informa Healthcare , 2013. Vol. 47, no 6, 329-334 p.
Keyword [en]
coronary artery disease, noninvasive stress imaging, remodeling
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-102849DOI: 10.3109/14017431.2013.857039ISI: 000327848900002OAI: diva2:683836

Funding Agencies|EU (FP7) framework program||

Available from: 2014-01-07 Created: 2014-01-02 Last updated: 2014-01-07

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Engvall, JanEbbers, Tino
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Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Clinical Physiology in Linköping
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