On/off-switchable electrochemical sensor for folicacid based on molecularly imprinted technology.
2013 (English)In: Electrochemistry communications, ISSN 1388-2481, E-ISSN 1873-1902, Vol. 36, 92-95 p.Article in journal (Refereed) Published
The combination of smart polymers with molecular imprinting offers a powerful tool to design more effective sensors and medical devices. In this study, a temperature sensitive amine-terminated poly(N-isopropylacrylamide) block with (N,N'-methylenebisacrylamide) cross-linker along with o-phenylenediamine was electropolymerised on a gold electrode in the presence of folic acid (FA) as template to produce an on/off-switchable molecularly imprinted polymer (MIP) affinity sensor for folic acid. Differential pulse voltammetry and cyclic voltammetry were used to characterise the FA-imprinted layer. Incubation of the MIP-modified electrode with FA resulted in a suppression of the ferro/ferricyanide redox process. The highest sensitivity of this temperature gated on/off-switchable folic acid sensor was achieved at 22 °C. Such switchable affinity materials offer considerable potential for the design of highly selective and controllable biosensors and immunoassays.
Place, publisher, year, edition, pages
2013. Vol. 36, 92-95 p.
MIP, Folic acid, biosensor, smart material
IdentifiersURN: urn:nbn:se:liu:diva-102941DOI: 10.1016/j.elecom.2013.09.014ISI: 000328927600023OAI: oai:DiVA.org:liu-102941DiVA: diva2:684763
FunderSwedish Research Council