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Assessment of beta-cell function in young patients with type 2 diabetes: arginine-stimulated insulin secretion may reflect beta-cell reserve
AstraZeneca R&D, Mölndal, Sweden.
AstraZeneca R&D, Mölndal, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Endocrinology.
Sahlgrenska Academy Hospital, Gothenburg, Sweden.
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2014 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 275, no 1, 39-48 p.Article in journal (Refereed) Published
Abstract [en]


Simple methods for the evaluation of dynamic β-cell function in epidemiological and clinical studies of patients with type 2 diabetes (T2D) are needed. The aim of this study was to evaluate the dynamic beta-cell function in young patients with T2D with different disease durations and treatments.


Overall, 54 subjects with T2D from the Diabetes Incidence Study in Sweden (DISS) and 23 healthy control participants were included in this cross-sectional study. Beta-cell function was assessed by intravenous (i.v.) administration of arginine followed by i.v. glucose. The acute insulin and C-peptide responses to arginine (AIRarg and Ac-pepRarg, respectively) and to glucose (AIRglu and Ac-pepRglu, respectively) were estimated. Homeostasis model assessment of β-cell function (HOMA-β) and C-peptide assessments were also used for comparisons between patients with T2D and control participants.


AIRarg and Ac-pepRarg, but not AIRglu and Ac-pepRglu, could differentiate between patients with different disease durations. AIRglu values were 89% (P < 0.001) lower and AIRarg values were 29% (P < 0.01) lower in patients with T2D compared with control participants. HOMA-β and fasting plasma C-peptide levels did not differ between the T2D and control groups.


In young patients with T2D, the insulin secretory response to i.v. glucose is markedly attenuated, whereas i.v. arginine-stimulated insulin release is better preserved and can distinguish between patients with different disease duration and antidiabetic therapies. This suggests that the i.v. arginine stimulation test may provide an estimate of functional beta-cell reserve.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2014. Vol. 275, no 1, 39-48 p.
Keyword [en]
type 2 diabetes, b-cell function
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-102970DOI: 10.1111/joim.12116ISI: 000328157100004OAI: diva2:685653

Funding Agencies|AstraZeneca||

Available from: 2014-01-09 Created: 2014-01-09 Last updated: 2014-11-27Bibliographically approved

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Arnqvist, Hans
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Division of Cell BiologyFaculty of Health SciencesDepartment of Endocrinology
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