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Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study
Linköping University, Department of Clinical and Experimental Medicine, Plastic Surgery, Hand Surgery and Burns. Linköping University, Faculty of Health Sciences. Berzelius Clinical Research Center, Berzelius Science Park, Linköping, Sweden.
Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, the Biomedical Centre, Uppsala, Sweden.
National Veterinary Institute, Uppsala, Sweden.
Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, the Biomedical Centre, Uppsala, Sweden.
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2009 (English)In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 2, no 4, 1908-1922 p.Article in journal (Refereed) Published
Abstract [en]

Spider silk is an interesting biomaterial for medical applications. Recently, a method for production of recombinant spider silk protein (4RepCT) that forms macroscopic fibres in physiological solution was developed. Herein, 4RepCT and Mersilk(TM) (control) fibres were implanted subcutaneously in rats for seven days, without any negative systemic or local reactions. The tissue response, characterised by infiltration of macrophages and multinucleated cells, was similar with both fibres, while only the 4RepCT-fibres supported ingrowth of fibroblasts and newly formed capillaries. This in vivo study indicates that 4RepCT-fibres are well tolerated and could be used for medical applications, e. g., tissue engineering.

Place, publisher, year, edition, pages
Basel, Switzerland: MDPI AG , 2009. Vol. 2, no 4, 1908-1922 p.
Keyword [en]
spider silk, recombinant, biocompatibility, in vivo
National Category
Materials Engineering
Identifiers
URN: urn:nbn:se:liu:diva-103169DOI: 10.3390/ma2041908ISI: 000208140200019OAI: oai:DiVA.org:liu-103169DiVA: diva2:687351
Available from: 2014-01-14 Created: 2014-01-14 Last updated: 2017-12-06Bibliographically approved

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Fredriksson, CamillaHuss, Fredrik

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Plastic Surgery, Hand Surgery and BurnsFaculty of Health SciencesDepartment of Plastic Surgery, Hand surgery and BurnsBurn Center
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