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Increased Serum S-TRAIL Level in Newly Diagnosed Stage-IV Lung Adenocarcinoma but not Squamous Cell Carcinoma is Correlated with Age and Smoking
Antalya Training and Research Hospital, Turkey Medstar Hospital, Turkey Medical Pk Hospital, Turkey .
Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Cukurova Univ, Turkey.
Antalya Training and Research Hospital, Turkey Academic Sinica, Taiwan .
Antalya Training and Research Hospital, Turkey Medstar Hospital, Turkey Medical Pk Hospital, Turkey .
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2013 (English)In: Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, Vol. 14, no 8, 4819-4822 p.Article in journal (Refereed) Published
Abstract [en]

Background: Lung cancer is the leading cause of cancer mortality in the world. Many factors can protect against or facilitate its development. A TNF family member TRAIL, has a complex physiological role beyond that of merely activating the apoptotic pathway in cancer cells. Vitamin D is converted to its active form locally in the lung, and is also thought to play an important role in lung health. Our goal was to investigate the possible clinical significance of serum sTRAIL and 1,25-dihydroxyvitamin D(3) levels in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Totals of 18 consecutive adenocarcinoma and 22 squamous cell carcinoma patients with stage-IV non-small cell lung cancer referred to our institute were included in this study. There were 12 men and 6 women, with ages ranging from 38 to 97 (mean 60.5) years with adenocarcinoma, and 20 men and 2 women, with ages ranging from 46 to 80 (mean 65) years with squamous cell carcinoma. Serum levels of sTRAIL and 1,25-dihydroxyvitamin D(3) were measured in all samples at the time of diagnosis. Results: sTRAIL levels in NSCLC patients were higher than in the control group. Although there was no correlation between patient survival and sTRAIL levels, the highest sTRAIL levels were correlated with age and cigarette smoking in the adenocarcinoma patients. sTRAIL level in healthy individuals were correlated with serum 1,25-dihydroxyvitamin D(3). Conclusions: Serum sTRAIL concentrations were increased in NSCLC patients, and correlated with age and smoking history, but not with overall survival.

Place, publisher, year, edition, pages
Asian Pacific Education Press Ltd. , 2013. Vol. 14, no 8, 4819-4822 p.
Keyword [en]
Soluble TRAIL; non-small cell lung cancer; adenocarcinoma; squamous cell carcinoma
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-103314DOI: 10.7314/APJCP.2013.14.8.4819ISI: 000328271800063OAI: oai:DiVA.org:liu-103314DiVA: diva2:688352
Available from: 2014-01-16 Created: 2014-01-16 Last updated: 2017-12-06

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