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Erythropoietin in cancer: a dilemma in risk therapy
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Karolinska Institute, Sweden .
2013 (English)In: Trends in endocrinology and metabolism, ISSN 1043-2760, E-ISSN 1879-3061, Vol. 24, no 4, 190-199 p.Article, review/survey (Refereed) Published
Abstract [en]

Erythropoietin (EPO) is a frequently prescribed drug for treatment of cancer-related and chemotherapy-induced anemia in cancer patients. Paradoxically, recent preclinical and clinical studies indicate that EPO could potentially accelerate tumor growth and jeopardize survival in cancer patients. In this review I critically discuss the current knowledge and broad biological functions of EPO in association with tumor growth, invasion, and angiogenesis. The emphasis is focused on discussing the complex interplay between EPO and other tumor-derived factors in angiogenesis, tumor growth, invasion, and metastasis. Understanding the multifarious functions of EPO and its reciprocal relation with other signaling pathways is crucial for developing more effective agents for cancer therapy and for minimizing risks for cancer patients.

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 24, no 4, 190-199 p.
Keyword [en]
angiogenesis, cancer therapy, erythropoietin, erythropoiesis, anemia
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-103401DOI: 10.1016/j.tem.2012.10.007ISI: 000317948300004OAI: diva2:689075

Funding Agencies|Swedish Research Council||Swedish Cancer Foundation||Karolinska Institute Foundation||Karolinska Institute||Tianjin Natural Science Foundation (CMM-Tianjin)|09ZCZDSF04400|Torsten Soderbergs foundation||European Union Integrated Project of Metoxia|222741|European Research Council (ERC) advanced grant ANGIOFAT|250021|

Available from: 2014-01-20 Created: 2014-01-20 Last updated: 2014-01-20

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Cao, Yihai
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Division of Cardiovascular MedicineFaculty of Health Sciences
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