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Efficacy of a Sclerostin Antibody Compared to a Low Dose of PTH on Metaphyseal Bone Healing
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
Lilly Research Labs, IN USA .
Lilly Research Labs, IN USA .
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2014 (English)In: Journal of Orthopaedic Research, ISSN 0736-0266, E-ISSN 1554-527X, Vol. 32, no 3, 471-476 p.Article in journal (Refereed) Published
Abstract [en]

We compared the effect of a sclerostin antibody to that of a clinically relevant dose of parathyroid hormone (PTH) in a rat model for metaphyseal bone healing. Screws of steel or poly methyl methacrylate (PMMA) were inserted bilaterally into the proximal tibia of young male rats. During 4 weeks the animals then received injections of either phosphate buffered saline (control), sclerostin antibody (25mg/kg, twice weekly) or PTH (5 mu g/kg, daily). The healing response around the screws was then assessed by mechanical testing and X-ray microtomography (mu CT). To distinguish between effects on healing and general effects on the skeleton, other untraumatized bone sites and serum biomarkers were also assessed. After 4 weeks of treatment, PTH yielded a 48% increase in screw pull-out force compared to control (p=0.03), while the antibody had no significant effect. In contrast, the antibody increased femoral cortical and vertebral strength where PTH had no significant effect. mu CT showed only slight changes that were statistically significant for the antibody mainly at cortical sites. The results suggest that a relatively low dose of PTH stimulates metaphyseal repair (screw fixation) specifically, whereas the sclerostin antibody has wide-spread effects, mainly on cortical bone, with less influence on metaphyseal healing.

Place, publisher, year, edition, pages
Wiley-Blackwell , 2014. Vol. 32, no 3, 471-476 p.
Keyword [en]
implant fixation; bone healing; mechanical testing; bone formation; Wnt-signaling
National Category
Orthopedics
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URN: urn:nbn:se:liu:diva-103861DOI: 10.1002/jor.22525ISI: 000329421500015OAI: oai:DiVA.org:liu-103861DiVA: diva2:692555
Available from: 2014-01-31 Created: 2014-01-30 Last updated: 2017-12-06

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Agholme, FredrikAspenberg, Per

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Agholme, FredrikAspenberg, Per
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Division of Inflammation MedicineFaculty of Health SciencesDepartment of Orthopaedics in Linköping
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