Pain and intramuscular release of algesic substances in the masseter muscle after experimental tooth-clenching exercises in healthy subjects
2013 (English)In: Journal of Oral & Facial Pain and Headache, ISSN 1064-6655, EISSN 2333-0376, Vol. 27, no 4, 350-360 p.Article in journal (Refereed) Published
To investigate whether experimental tooth clenching leads to a release of algesic substances in the masseter muscle.
Thirty healthy subjects (16 females, 14 males) participated. During two sessions, separated by at least 1 week, intramuscular microdialysis was performed to collect masseter muscle 5-hydroxytryptamine (5-HT) and glutamate as well as the metabolic markers pyruvate and lactate. Two hours after the start of microdialysis, participants were randomized to a 20-min repetitive experimental tooth-clenching task (50% of maximal voluntary contraction) or a control session (no clenching). Pain and fatigue were measured throughout. The Friedman and Wilcoxon tests were used for statistical analyses.
No alterations were observed in the concentrations of 5-HT, glutamate, pyruvate, and lactate over time in the clenching or control session, or between sessions at various time points. Pain (P < .01) and fatigue (P < .01) increased significantly over time in the clenching session and were significantly higher after clenching than in the control session (P < .01).
Low levels of pain and fatigue developed with this experimental tooth-clenching model, but they were not associated with an altered release of 5-HT, glutamate, lactate, or pyruvate. More research is required to elucidate the peripheral release of algesic substances in response to tooth clenching.
Place, publisher, year, edition, pages
Quintessence Publishing , 2013. Vol. 27, no 4, 350-360 p.
Adult Bite Force, Bruxism/metabolism, Chi-Square Distributeion, Facial Pain/metabolism/*physiopathology, Female, Glutamic Acid/secretion, Humans, Jaw/*physiology, Lactic Acid/metabolism, Male, Masseter Muscle/*metabolism/physiology, Masseter Muscle/*metabolism/physiology, Muscle Contraction/*physiology, Muscle Fatigue/*physiologyPyruvic Acid/metabolism, Serotonin/*secretion, Single-Blind Method, Statistics, Nonparametric, Young Adult
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-104233DOI: 10.11607/jop.1170PubMedID: 24171185OAI: oai:DiVA.org:liu-104233DiVA: diva2:695707