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Pain and intramuscular release of algesic substances in the masseter muscle after experimental tooth-clenching exercises in healthy subjects
Malmö University, Sweden.
Linköping University, Department of Medical and Health Sciences, Rehabilitation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center. Östergötlands Läns Landsting, Heart and Medicine Center, Occupational and Environmental Medicine Center.
Linköping University, Department of Medical and Health Sciences, Rehabilitation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Malmö University, Sweden.
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2013 (English)In: Journal of Orofacial Pain, ISSN 1064-6655, E-ISSN 1945-3396, Vol. 27, no 4, 350-360 p.Article in journal (Refereed) Published
Abstract [en]

AIMS:

To investigate whether experimental tooth clenching leads to a release of algesic substances in the masseter muscle.

METHODS:

Thirty healthy subjects (16 females, 14 males) participated. During two sessions, separated by at least 1 week, intramuscular microdialysis was performed to collect masseter muscle 5-hydroxytryptamine (5-HT) and glutamate as well as the metabolic markers pyruvate and lactate. Two hours after the start of microdialysis, participants were randomized to a 20-min repetitive experimental tooth-clenching task (50% of maximal voluntary contraction) or a control session (no clenching). Pain and fatigue were measured throughout. The Friedman and Wilcoxon tests were used for statistical analyses.

RESULTS:

No alterations were observed in the concentrations of 5-HT, glutamate, pyruvate, and lactate over time in the clenching or control session, or between sessions at various time points. Pain (P < .01) and fatigue (P < .01) increased significantly over time in the clenching session and were significantly higher after clenching than in the control session (P < .01).

CONCLUSION:

Low levels of pain and fatigue developed with this experimental tooth-clenching model, but they were not associated with an altered release of 5-HT, glutamate, lactate, or pyruvate. More research is required to elucidate the peripheral release of algesic substances in response to tooth clenching.

Place, publisher, year, edition, pages
Quintessence Publishing , 2013. Vol. 27, no 4, 350-360 p.
Keyword [en]
Adult Bite Force, Bruxism/metabolism, Chi-Square Distributeion, Facial Pain/metabolism/*physiopathology, Female, Glutamic Acid/secretion, Humans, Jaw/*physiology, Lactic Acid/metabolism, Male, Masseter Muscle/*metabolism/physiology, Masseter Muscle/*metabolism/physiology, Muscle Contraction/*physiology, Muscle Fatigue/*physiologyPyruvic Acid/metabolism, Serotonin/*secretion, Single-Blind Method, Statistics, Nonparametric, Young Adult
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-104233DOI: 10.11607/jop.1170PubMedID: 24171185OAI: oai:DiVA.org:liu-104233DiVA: diva2:695707
Available from: 2014-02-12 Created: 2014-02-12 Last updated: 2017-12-06Bibliographically approved

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Ghafouri, BijarGerdle, Björn

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Rehabilitation MedicineFaculty of Health SciencesPain and Rehabilitation CenterOccupational and Environmental Medicine Center
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