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The impact of latent confounders in directed network analysis in neuroscience
University of Freiburg, Germany .
Maastricht University, Netherlands .
University of Aberdeen, Scotland .
University of Aberdeen, Scotland .
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2013 (English)In: Philosophical Transactions. Series A: Mathematical, physical, and engineering science, ISSN 1364-503X, Vol. 371, no 1997Article in journal (Refereed) Published
Abstract [en]

In the analysis of neuroscience data, the identification of task-related causal relationships between various areas of the brain gives insights about the network of physiological pathways that are active during the task. One increasingly used approach to identify causal connectivity uses the concept of Granger causality that exploits predictability of activity in one region by past activity in other regions of the brain. Owing to the complexity of the data, selecting components for the analysis of causality as a preprocessing step has to be performed. This includes predetermined-and often arbitrary-exclusion of information. Therefore, the system is confounded by latent sources. In this paper, the effect of latent confounders is demonstrated, and paths of influence among three components are studied. While methods for analysing Granger causality are commonly based on linear vector autoregressive models, the effects of latent confounders are expected to be present also in nonlinear systems. Therefore, all analyses are also performed for a simulated nonlinear system and discussed with regard to applications in neuroscience.

Place, publisher, year, edition, pages
Royal Society , 2013. Vol. 371, no 1997
Keyword [en]
Granger causality; renormalized partial directed coherence; vector autoregressive modelling; latent confounders
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-104850DOI: 10.1098/rsta.2011.0612ISI: 000330309500002OAI: diva2:699596
Available from: 2014-02-28 Created: 2014-02-28 Last updated: 2014-02-28

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Timmer, Jens
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Division of Cell BiologyFaculty of Health Sciences
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