Concentrations of Cocaine and Benzoylecgonine in Femoral Blood from Cocaine-Related Deaths Compared with Venous Blood from Impaired Drivers
2014 (English)In: Journal of Analytical Toxicology, ISSN 0146-4760, Vol. 38, no 1, 46-51 p.Article in journal (Refereed) Published
The concentrations of cocaine and its major metabolite benzoylecgonine (BZE) were determined in femoral blood from 132 cocaine-related deaths and compared with venous blood from 988 apprehended drivers. Cocaine and BZE were determined by solid-phase extraction and isotope dilution gas chromatographymass spectrometry with limits of quantitation of 0.02 mg/L for both substances. Significantly more men (9598) than women (25) abused cocaine, although their mean age was about the same (2930 years). Mean age (SD) of cocaine-related deaths was 29 7 years, which was not significantly different from 30 8 years in traffic cases (P 0.05). The median concentration of cocaine in blood in 61 fatalities was 0.10 mg/L compared with 0.06 mg/L in traffic cases (P 0.001). In drug intoxication deaths, the median concentration of cocaine was 0.13 mg/L (N 25), which was not significantly different from 0.09 mg/L (N 36) in other causes of death. Cocaine-related deaths mostly involved mixed drug intoxications including co-ingestion of heroin, cannabis, amphetamines as well as legal drugs, such as benzodiazepines and/or ethanol. The concentrations of cocaine in blood from living and deceased persons overlapped, which makes it infeasible to predict toxicity from the analytical toxicology results alone.
Place, publisher, year, edition, pages
Oxford University Press (OUP): Policy F , 2014. Vol. 38, no 1, 46-51 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-104840DOI: 10.1093/jat/bkt094ISI: 000330446000007OAI: oai:DiVA.org:liu-104840DiVA: diva2:699606