Shorter telomere length is linked to brain atrophy and white matter hyperintensities.
2014 (English)In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 43, no 2, 212-217 p.Article in journal (Refereed) Published
Background: leukocyte telomere length (TL) is considered a marker of biological aging. Several studies have investigated the link between leukocyte TL and aging-associated functional attributes of the brain, but no prior study has investigated whether TL can be linked to brain atrophy and white matter hyperintensities (WMHs); two prominent structural manifestations of brain aging.
Methods: we investigated whether leukocyte TL was related to brain atrophy and WMHs in a sample of 102 non-demented individuals aged 64–75 years.
Results: shorter TL was related to greater degree of subcortical atrophy (β = −0.217, P = 0.034), but not to cortical atrophy. Furthermore, TL was 371 bp shorter (P = 0.041) in participants exhibiting subcortical WMHs, and 552 bp shorter (P = 0.009) in older participants exhibiting periventricular WMHs.
Conclusion: this study provides the first evidence of leukocyte TL being associated with cerebral subcortical atrophy and WMHs, lending further support to the concept of TL as a marker of biological aging, and in particular that of the aging brain.
Place, publisher, year, edition, pages
Oxford University Press (OUP) , 2014. Vol. 43, no 2, 212-217 p.
IdentifiersURN: urn:nbn:se:liu:diva-104971DOI: 10.1093/ageing/aft172ISI: 000332028600012OAI: oai:DiVA.org:liu-104971DiVA: diva2:702429
FunderSwedish Research Council, 2009-3413Swedish Research Council, 315-2004-6977