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Livin expression is an independent factor in rectal cancer patients with or without preoperative radiotherapy
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
University of Örebro, Sweden .
Karolinska University Hospital, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
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2013 (English)In: Radiation Oncology, ISSN 1748-717X, Vol. 8, no 281Article in journal (Refereed) Published
Abstract [en]

Background: This study was aimed to investigate the expression significance of Livin in relation to radiotherapy (RT), clinicopathological and biological factors of rectal cancer patients. Methods: This study included 144 primary rectal cancer patients who participated in a Swedish clinical trial of preoperative radiotherapy. Tissue microarray samples from the excised primary rectal cancers, normal mucosa and lymph node metastases were immunostained with Livin antibody. The proliferation of colon cancer cell lines SW620 and RKO was assayed after Livin knock-down. Results: The expression of Livin was significantly increased from adjacent (P = 0.051) or distant (P = 0.028) normal mucosa to primary tumors. 15.4% (2/13) and 39.7% (52/131) patients with Livin-negative and positive tumors died at 180 months after surgery, and the difference tended to be statistically significant (P = 0.091). In multivariate analyses, the difference achieved statistical significance, independent of TNM stage, local and distant recurrence, grade of differentiation, gender, and age (odds ratio = 5.09, 95% CI: 1.01-25.64, P = 0.048). The in vitro study indicated colon cancer cells with Livin knock-down exhibited decreased proliferation compared with controls after RT. Conclusions: The expression of Livin was was independently related to survival in rectal cancer patients, suggesting Livin as a useful prognostic factor for rectal cancer patients.

Place, publisher, year, edition, pages
BioMed Central , 2013. Vol. 8, no 281
Keyword [en]
Rectal cancer; Livin; Radiotherapy
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-105255DOI: 10.1186/1748-717X-8-281ISI: 000331620900002OAI: diva2:705025
Available from: 2014-03-14 Created: 2014-03-14 Last updated: 2014-03-18

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Ding, Zhen-YuOlsson, BirgitSun, Xiao-Feng
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