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Cell adhesion molecules and their relation to (cancer) cell stemness
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0001-6105-1213
University of Toronto, ON, Canada.
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2014 (English)In: Carcinogenesis, ISSN 0143-3334, E-ISSN 1460-2180, Vol. 35, no 4, 747-759 p.Article, review/survey (Refereed) Published
Abstract [en]

Despite decades of search for anticancer drugs targeting solid tumors, this group of diseases remains largely incurable, especially if in advanced, metastatic stage. In this review, we draw comparison between reprogramming and carcinogenesis, as well as between stem cells (SCs) and cancer stem cells (CSCs), focusing on changing garniture of adhesion molecules. Furthermore, we elaborate on the role of adhesion molecules in the regulation of (cancer) SCs division (symmetric or asymmetric), and in evolving interactions between CSCs and extracellular matrix. Among other aspects, we analyze the role and changes of expression of key adhesion molecules as cancer progresses and metastases develop. Here, the role of cadherins, integrins, as well as selected transcription factors like Twist and Snail is highlighted, not only in the regulation of epithelial-to-mesenchymal transition but also in the avoidance of anoikis. Finally, we briefly discuss recent developments and new strategies targeting CSCs, which focus on adhesion molecules or targeting tumor vasculature.

Place, publisher, year, edition, pages
Oxford University Press, 2014. Vol. 35, no 4, 747-759 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-105306DOI: 10.1093/carcin/bgu045ISI: 000335001800002OAI: oai:DiVA.org:liu-105306DiVA: diva2:705576
Available from: 2014-03-17 Created: 2014-03-17 Last updated: 2017-12-05Bibliographically approved

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Farahani, EnsiehPatra, Hirak KumarJangamreddy, Jaganmohan ReddyBatakis, PetrosWiechec, Emilia

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Farahani, EnsiehPatra, Hirak KumarJangamreddy, Jaganmohan ReddyBatakis, PetrosWiechec, Emilia
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Division of Cell BiologyFaculty of Health SciencesDepartment of Physics, Chemistry and BiologyThe Institute of TechnologyBiology
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Carcinogenesis
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