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General immune dampening is associated with disturbed metabolism at diagnosis of type 1 diabetes
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
Jonköping University, Sweden Ryhov County Hospital, Sweden .
2014 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 75, no 1, 45-50 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Type 1 diabetes (T1D) is a serious diagnosis with the prospect of grave short- and long-term complications and even death if poorly managed. An attempt has been made to describe how clinical and immunological deviations might influence each other close to the diagnosis of T1D. METHODS: Sixty-nine newly diagnosed T1D children were studied together with a reference group of 30 healthy children. Cytokines (interleukin (IL)-6, IL-10, IL-13, IL-17, interferon-gamma, and tumor necrosis factor-alpha) were detected in in vitro culture by multiplex fluorochrome technique. Information of clinical status of the patients such as BMI, weight loss, pubertal stage, duration of symptoms, previous and/or ongoing infections, insulin requirement, and ketoacidosis were gathered together with the analysis of C-peptide and glycosylated hemoglobin (HbA1c). RESULTS: In general, low cytokine secretion was found at diagnosis of T1D. However, high C-peptide, short duration of symptoms, or an infection prior to diagnosis was associated with increased immune activity including proinflammatory, Th2-associated, and Tr1-associated cytokines. In contrast, ketoacidosis and later pubertal stage at onset of disease were more related to a Th1-prone response. CONCLUSION: There is a general immune dampening at diagnosis of T1D, which appears to be related to the metabolic state close to diagnosis.

Place, publisher, year, edition, pages
Nature Publishing Group: Open Access Hybrid Model Option A , 2014. Vol. 75, no 1, 45-50 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-105430DOI: 10.1038/pr.2013.167ISI: 000331157600007OAI: oai:DiVA.org:liu-105430DiVA: diva2:706626
Available from: 2014-03-21 Created: 2014-03-21 Last updated: 2017-12-05

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Rydén, AnnaLudvigsson, JohnnyFredrikson, Mats

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Division of Clinical SciencesFaculty of Health SciencesDepartment of Paediatrics in LinköpingDivision of Inflammation Medicine
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