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Associations of genetic polymorphisms in the renin-angiotensin system with central aortic and ambulatory blood pressure in type 2 diabetic patients
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in West Östergötland, Primary Health Care in Motala.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Endocrinology.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.ORCID iD: 0000-0002-9095-403X
2014 (English)In: jraas. Journal of the renin-angiotensin-aldosterone system, ISSN 1470-3203, E-ISSN 1752-8976, Vol. 15, no 1, 61-68 p.Article in journal (Refereed) Published
Abstract [en]

Patients with type 2 diabetes (T2D) are at high risk of developing hypertension and related cardiovascular disease. The renin-angiotensin system (RAS) plays a central role in regulation of blood pressure (BP). Accordingly, each component of this system represents a potential candidate in the etiology of hypertension. This study investigated the impact of polymorphisms within the RAS on ambulatory and central BP in T2D subjects. A cohort of 761 subjects (55-65 years) with T2D was studied. Ambulatory and central BP were measured, and ACE I/D genotype, angiotensinogen M235T, renin rs6693954 and ATR1-A1166C polymorphisms were analyzed. Women carrying the AA-genotype had lower 24-hour and day-time systolic and diastolic BP (pless than0.05), and lower night-time and central diastolic BP (pless than0.05), compared to T allele carriers. In men, the AA-genotype was instead associated with higher central diastolic BP (p=0.018) and higher augmentation index (p=0.016). Further, the associations between the renin rs6693954 SNP and diastolic BP were strongly gender dependent (p less than= 0.001). In T2D patients, there is a gender-dependent association of the renin rs6693954 SNP with central and ambulatory BP. Women carrying the renin rs6693954 AA-genotype may be protected against the higher BP seen in men with the same genotype.

Place, publisher, year, edition, pages
SAGE Publications (UK and US) , 2014. Vol. 15, no 1, 61-68 p.
Keyword [en]
rs6693954; central hemodynamics; Hypertension; gender; T2D
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-105409DOI: 10.1177/1470320312474052ISI: 000331368800009OAI: oai:DiVA.org:liu-105409DiVA: diva2:706661
Available from: 2014-03-21 Created: 2014-03-21 Last updated: 2017-12-05

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Ljungberg, LizaJohan Östgren, CarlNyström, Fredrik HLänne, Toste

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Ljungberg, LizaJohan Östgren, CarlNyström, Fredrik HLänne, Toste
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Division of Cardiovascular MedicineFaculty of Health SciencesDivision of Community MedicinePrimary Health Care in MotalaDepartment of EndocrinologyDepartment of Thoracic and Vascular Surgery
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jraas. Journal of the renin-angiotensin-aldosterone system
Medical and Health Sciences

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