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Concentrations of diazepam and nordiazepam in 1,000 blood samples from apprehended drivers--therapeutic use or abuse of anxiolytics?
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences. Department of Forensic Genetics and Forensic Toxicology, National.
Department of Forensic Genetics and Forensic Toxicology, National.
2013 (English)In: Journal of Pharmacy Practice, ISSN 0897-1900, E-ISSN 1531-1937, Vol. 26, no 3, 198-203 p.Article in journal (Refereed) Published
Abstract [en]

Using an in-house forensic toxicology database, we selected 1000 cases of driving under the influence of drugs (DUIDs) over a 12-month period if diazepam (D) and nordiazepam (ND) were both present in the blood samples. Quantitative analysis of D and ND in blood was done by solvent extraction (butyl acetate) and capillary column gas chromatography (GC) with a nitrogen-phosphorous (N-P) detector. The limits of quantitation of this analytical method for D and ND in blood were 0.05 mg/L. The correlation between D and ND concentrations in blood was statistically significant (r = .58, P < .001), as expected for a parent drug and its primary metabolite. However, the frequency distributions were markedly skewed to the right with mean (median) and highest concentrations of 0.37 (0.20) and 6.1 mg/L for D and 0.39 (0.20) and 5.6 mg/L for ND. The mean (median) total concentration (D + ND) was 0.76 mg/L (0.50 mg/L), and the concentration ratios D/ND and ND/D were 1.29 (median 0.95) and 1.41 (median 1.06), respectively. In 90 cases (9%), the concentration of D in blood exceeded 0.83 mg/L, which corresponds to an upper therapeutic limit in plasma (∼1.5 mg/L), assuming a plasma/blood distribution ratio of 1.8:1.

Place, publisher, year, edition, pages
2013. Vol. 26, no 3, 198-203 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-105550DOI: 10.1177/0897190012451910PubMedID: 22797834OAI: diva2:708253
Available from: 2014-03-27 Created: 2014-03-27 Last updated: 2014-03-27

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Jones, Alan W
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