liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Gold-Nanoparticle-Assisted Self-Assembly of Chemical Gradients with Tunable Sub-50 nm Molecular Domains
University of Gothenburg, Sweden .
University of Gothenburg, Sweden .
University of Gothenburg, Sweden .
University of Gothenburg, Sweden .
Show others and affiliations
2014 (English)In: Particle & particle systems characterization, ISSN 0934-0866, E-ISSN 1521-4117, Vol. 31, no 2, 209-218 p.Article in journal (Refereed) Published
Abstract [en]

A simple and efficient principle for nanopatterning with wide applicability in the sub-50 nanometer regime is chemisorption of nanoparticles; at homogeneous substrates, particles carrying surface charge may spontaneously self-organize due to the electrostatic repulsion between adjacent particles. Guided by this principle, a method is presented to design, self-assemble, and chemically functionalize gradient nanopatterns where the size of molecular domains can be tuned to match the level corresponding to single protein binding events. To modulate the binding of negatively charged gold nanoparticles both locally (less than100 nm) and globally (greater than100 m) onto a single modified gold substrate, ion diffusion is used to achieve spatial control of the particles mutual electrostatic interactions. By subsequent tailoring of different molecules to surface-immobilized particles and the void areas surrounding them, nanopatterns are obtained with variable chemical domains along the gradient surface. Fimbriated Escherichia coli bacteria are bound to gradient nanopatterns with similar molecular composition and macroscopic contact angle, but different sizes of nanoscopic presentation of adhesive (hydrophobic) and repellent poly(ethylene) glycol (PEG) domains. It is shown that small hydrophobic domains, similar in size to the diameter of the bacterial fimbriae, supported firmly attached bacteria resembling catch-bond binding, whereas a high number of loosely adhered bacteria are observed on larger hydrophobic domains.

Place, publisher, year, edition, pages
Wiley-VCH Verlag , 2014. Vol. 31, no 2, 209-218 p.
Keyword [en]
bacterial adhesion; chemical gradients; gold nanoparticles; imaging surface plasmon resonance; protein nanopatterns
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-105760DOI: 10.1002/ppsc.201300154ISI: 000331904500005OAI: diva2:710299
Available from: 2014-04-07 Created: 2014-04-04 Last updated: 2014-04-07

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Andersson, OlofLiedberg, Bo
By organisation
Sensor Science and Molecular PhysicsThe Institute of Technology
In the same journal
Particle & particle systems characterization
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 82 hits
ReferencesLink to record
Permanent link

Direct link