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Treatment of comorbid alcohol use disorders and depression with cognitive-behavioural therapy and motivational interviewing: a meta-analysis
Vrije Univ Amsterdam, Netherlands Vrije Univ Amsterdam, Netherlands Vrije Univ Amsterdam Med Ctr, Netherlands Leuphana Univ Luneburg, Germany.
Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences. Karolinska Institute, Sweden .ORCID iD: 0000-0003-4753-6745
Vrije University of Amsterdam, Netherlands .
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2014 (English)In: Addiction, ISSN 0965-2140, E-ISSN 1360-0443, Vol. 109, no 3, 394-406 p.Article, review/survey (Refereed) Published
Abstract [en]

Background and AimsTo review published studies on the effectiveness of combining cognitive-behavioural therapy (CBT) and motivational interviewing (MI) to treat comorbid clinical and subclinical alcohol use disorder (AUD) and major depression (MDD) and estimate the effect of this compared with usual care. MethodsWe conducted systematic literature searches in PubMed, PsycINFO and Embase up to June 2013 and identified additional studies through cross-references in included studies and systematic reviews. Twelve studies comprising 1721 patients met our inclusion criteria. The studies had sufficient statistical power to detect small effect sizes. ResultsCBT/MI proved effective for treating subclinical and clinical AUD and MDD compared with controls, with small overall effect sizes at post-treatment [g=0.17, confidence interval (CI)=0.07-0.28, Pless than0.001 for decrease of alcohol consumption and g=0.27, CI: 0.13-0.41, Pless than0.001 for decrease of symptoms of depression, respectively]. Subgroup analyses revealed no significant differences for both AUD and MDD. However, digital interventions showed a higher effect size for depression than face-to-face interventions (g=0.73 and g=0.23, respectively, P=0.030). ConclusionsCombined cognitive-behavioural therapy and motivational interviewing for clinical or subclinical depressive and alcohol use disorders has a small but clinically significant effect in treatment outcomes compared with treatment as usual.

Place, publisher, year, edition, pages
Wiley , 2014. Vol. 109, no 3, 394-406 p.
Keyword [en]
Alcohol use disorders; cognitive-behavioural therapy; comorbidity; major depression; meta-analysis; motivational interviewing; randomized controlled trials; treatment effect
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-105744DOI: 10.1111/add.12441ISI: 000331098300019OAI: diva2:710353
Available from: 2014-04-07 Created: 2014-04-04 Last updated: 2014-11-28

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