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Preterm lambs given intravenous dopamine show increased dopamine in their cerebrospinal fluid
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Monash University, Australia .
Monash University, Australia .
Monash Medical Centre, Australia Monash University, Australia .
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2014 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 103, no 3, 337-342 p.Article in journal (Refereed) Published
Abstract [en]

AimDopamine is used as an inotropic medication in preterm infants. The preterm human blood brain barrier (BBB) is permeable to intravascular dopamine, and the impact of exogenous dopamine on the preterm brain remains unknown. The preterm lamb model may be suitable for studying the cerebral impact of dopamine therapy whether its BBB permeability is similar to preterm human infants. We aimed to examine BBB permeability to exogenous dopamine in the preterm lamb, by measuring dopamine levels in the cerebrospinal fluid (CSF). MethodsNine preterm foetal lambs (125-130days, term=147days) were given either dopamine at 10g/kg/min (dopamine, n=4) or saline (control, n=5). CSF, and plasma samples were taken for dopamine assay. ResultsThe median (range) baseline CSF dopamine level for the combined control and dopamine groups (n=9) was 0.10(0.03-0.16)ng/mL, and baseline plasma dopamine was 0.30(0.13-0.84) ng/mL. The dopamine lambs showed increase in CSF dopamine to 3.91(1.87-11.35)ng/mL with plasma dopamine increased to 14.2 (9.1-57.9)ng/mL. No change was found in the control lambs. ConclusionIn the preterm lamb, the BBB permeability and pharmacokinetics to dopamine infusion are similar to findings in the preterm human infant, supporting applicability of the preterm lamb model for studying effects of dopamine infusion in the preterm human brain.

Place, publisher, year, edition, pages
Wiley , 2014. Vol. 103, no 3, 337-342 p.
Keyword [en]
Blood brain barrier; Dopamine; Hypotension; Infants; Preterm
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-105743DOI: 10.1111/apa.12520ISI: 000331270000031OAI: diva2:710354
Available from: 2014-04-07 Created: 2014-04-04 Last updated: 2015-03-30

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Olhager, Elisabeth
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Division of Clinical SciencesFaculty of Health SciencesDepartment of Paediatrics in Linköping
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