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Changes in Temporal and Spectral Functions of the Auditory Periphery Due to Aging and Noise-induced Cochlear Pathologies: A Comparative Clinical Study
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-3350-8997
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuroscience. Linköping University, Faculty of Health Sciences.
2014 (English)Manuscript (preprint) (Other academic)
Abstract [en]

Objective: This study includes a battery of psychoacoustical and electrophysiological tests to quantitatively investigate the changes in the frequency and the temporal features of the human auditory periphery caused by aging (presbyacusis) and noise-induced lesions, two common types of sensorineural hearing impairments. The scores are comparatively analyzed.

Design: These clinical experiments have been implemented in MATLAB software.

Study sample: 20 normal hearing adults (aged 30-54), 20 older hearing-impaired subjects (aged 65-70) with no history of Ototoxic medication or noise exposure and 7 adult men with a traceable noise-induced hearing impairment.

Results: The observed temporal and spectral declines are generally consistent with the high-frequency audiometric loss depicted by the audiogram, for each group. Moreover, the test battery provides valuable information on the frequency sensitivity, temporal resolution, loudness growth, compression and otoacoustic emissions.

Conclusion: These scores are compared with the predictions of a physiologicallybased cochlear model to provide evidence about specific inner-ear pathologies, beyond what the audiogram can indicate. Among these 7 clinical experiments, the results from the forward temporal masking test, the categorical loudness discrimination test and the distortion product otoacoustic emission test provide the most differential information about the underlying cellular lesions. The results indicate that the reduction in the temporal resolution is substantially age-relate since the presbyacusis listeners, unlike the other groups, obtained almost no benefit from the temporal cues provided by the gap duration at any of the experiments. Moreover, the results suggest that the DPOAEs reflect the cellular lesions associated with the acoustic overstimulation rather than the age-related strial degenerations.

Place, publisher, year, edition, pages
2014.
Keyword [en]
Inner ear pathologies, Cochlear lesion, Sensorineural hearing impairment, Auditory models
National Category
Otorhinolaryngology Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-105809OAI: oai:DiVA.org:liu-105809DiVA: diva2:710709
Available from: 2014-04-08 Created: 2014-04-08 Last updated: 2015-04-01Bibliographically approved
In thesis
1. Effects of Specific Cochlear Pathologies on the Auditory Functions: Modelling, Simulations and Clinical Implications
Open this publication in new window or tab >>Effects of Specific Cochlear Pathologies on the Auditory Functions: Modelling, Simulations and Clinical Implications
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A hearing impairment is primarily diagnosed by measuring the hearing thresholds at a range of auditory frequencies (air-conduction audiometry). Although this clinical procedure is simple, affordable, reliable and fast, it does not offer differential information about origins of the hearing impairment. The main goal of this thesis is to quantitatively link specific cochlear pathologies to certain changes in the spectral and temporal characteristics of the auditory system. This can help better understand the underlying mechanisms associated with sensorineural hearing impairments, beyond what is shown in the audiogram. Here, an electromechanical signal-transmission model is devised in MATLAB where the parameters of the model convey biological interpretations of mammalian cochlear structures. The model is exploited to simulate the cell-level cochlear pathologies associated with two common types of sensorineural hearing impairments, 1: presbyacusis (age-related hearing impairment) and, 2: noise-induced hearing impairment. Furthermore, a clinical study, consisting of different psychoacoustic and physiological tests, was performed to trace and validate the model predictions in human. The results of the clinical tests were collated and compared with the model predictions, showing a reasonable agreement. In summary, the present model provides a biophysical foundation for simulating the effect of specific cellular lesions, due to different inner-ear diseases and external insults, on the entire cochlear mechanism and thereby on the whole auditory system. This is a multidisciplinary work in the sense that it connects the ‘biological processes’ with ‘acoustic modelling’ and ‘clinical audiology’ in a translational context.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2014. 57 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1400Studies from the Swedish Institute for Disability Research, ISSN 1650-1128 ; 60
Keyword
Auditory modeling, cochlear mechanics, sensorineural hearing impairment, age-related hearing loss, noise-induced hearing loss, inner ear pathologies
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-105810 (URN)10.3384/diss.diva-105810 (DOI)978-91-7519-365-6 (ISBN)
Public defence
2014-04-28, Nils Holger salen, entrance 71, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Opponent
Supervisors
Available from: 2014-04-08 Created: 2014-04-08 Last updated: 2014-10-08Bibliographically approved

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Saremi, AminStenfelt, StefanMäki-Torkko, Elina

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