Effects of Specific Cochlear Pathologies on the Auditory Functions: Modelling, Simulations and Clinical Implications
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
A hearing impairment is primarily diagnosed by measuring the hearing thresholds at a range of auditory frequencies (air-conduction audiometry). Although this clinical procedure is simple, affordable, reliable and fast, it does not offer differential information about origins of the hearing impairment. The main goal of this thesis is to quantitatively link specific cochlear pathologies to certain changes in the spectral and temporal characteristics of the auditory system. This can help better understand the underlying mechanisms associated with sensorineural hearing impairments, beyond what is shown in the audiogram. Here, an electromechanical signal-transmission model is devised in MATLAB where the parameters of the model convey biological interpretations of mammalian cochlear structures. The model is exploited to simulate the cell-level cochlear pathologies associated with two common types of sensorineural hearing impairments, 1: presbyacusis (age-related hearing impairment) and, 2: noise-induced hearing impairment. Furthermore, a clinical study, consisting of different psychoacoustic and physiological tests, was performed to trace and validate the model predictions in human. The results of the clinical tests were collated and compared with the model predictions, showing a reasonable agreement. In summary, the present model provides a biophysical foundation for simulating the effect of specific cellular lesions, due to different inner-ear diseases and external insults, on the entire cochlear mechanism and thereby on the whole auditory system. This is a multidisciplinary work in the sense that it connects the ‘biological processes’ with ‘acoustic modelling’ and ‘clinical audiology’ in a translational context.
Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2014. , 57 p.
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1400Studies from the Swedish Institute for Disability Research, ISSN 1650-1128 ; 60
Auditory modeling, cochlear mechanics, sensorineural hearing impairment, age-related hearing loss, noise-induced hearing loss, inner ear pathologies
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-105810DOI: 10.3384/diss.diva-105810ISBN: 978-91-7519-365-6 (print)OAI: oai:DiVA.org:liu-105810DiVA: diva2:710714
2014-04-28, Nils Holger salen, entrance 71, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Elliott, Steve, Professor
Stenfelt, Stefan, Professor
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