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The role of pleiotropy and linkage in genes affecting a sexual ornament and bone allocation in the chicken
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, The Institute of Technology. (AVIAN Behavioural Genomics and Physiology group)ORCID iD: 0000-0003-1262-4585
Department of Medical Biochemistry and Michrobiology, BMC, Uppsala University, Sweden.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, The Institute of Technology. (AVIAN Behavioural Genomics and Physiology group)
Research group of Autoimmunity, Akademiska sjukhuset, Uppsala University, Sweden.
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2014 (English)In: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 23, no 9, 2275-2286 p.Article in journal (Refereed) Published
Abstract [en]

Sexual selection and the ornaments that inform such choices have been extensively studied, particularly from a phenotypic perspective. Although more is being revealed about the genetic architecture of sexual ornaments, much still remains to be discovered. The comb of the chicken is one of the most widely recognized sexual ornaments, which has been shown to be correlated with both fecundity and bone allocation. In this study, we use a combination of multiple intercrosses between White Leghorn populations and wild-derived Red Junglefowl to, first, map quantitative trait loci (QTL) for bone allocation and, second, to identify expression QTL that correlate and colocalize with comb mass. These candidate quantitative genes were then assessed for potential pleiotropic effects on bone tissue and fecundity traits. We identify genes that correlate with both relative comb mass and bone traits suggesting a combination of both pleiotropy and linkage mediates gene regulatory variation in these traits.

Place, publisher, year, edition, pages
John Wiley & Sons, 2014. Vol. 23, no 9, 2275-2286 p.
Keyword [en]
bone allocation, domestication, QTG, QTL, sexual selection
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-105936DOI: 10.1111/mec.12723ISI: 000334908100013OAI: diva2:712387
Available from: 2014-04-15 Created: 2014-04-15 Last updated: 2015-11-02
In thesis
1. Genomics of chicken domestication and feralisation
Open this publication in new window or tab >>Genomics of chicken domestication and feralisation
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Domestication can serve as a study system of rapid evolutionary change with wide-ranging effects on traits in animals. The chicken was domesticated from the Red Junglefowl and has diverged in behaviour, morphology and life history traits. Conversely, feralisation is a more recent process when domestic animals are again exposed and respond to an environment outside of human husbandry. Linkage-based quantitative trait locus (QTL) mapping has been used to localise genetic variants that affect domestication traits in the chicken genome. Because of the limited resolution of linkage mapping, the QTL regions associated with domestication traits are often broad and contain many genes. One approach to help sort out potential causative genes is to measure gene expression as an intermediary molecular phenotype. In this dissertation, expression quantitative trait locus (eQTL) mapping of gene expression traits is used to search for potential causative genes for domestication traits in the chicken. Expression quantitative trait loci were mapped across the whole genome in bone and hypothalamus samples, and targeted at QTL regions in the base of the comb. These studies have resulted in candidate quantitative trait genes, supported by genetic and gene expression evidence, for relative comb mass, bone allocation, egg production and fearful behaviour as measured in an open field test. Secondly, a population genomics approach was used to study the molecular basis of feralisation in a free-range feral chicken population from the Pacific island of Kauai. Mitochondrial DNA sequences and phenotypic observations establish the hybrid origin of this population as a mixture of wild and domestic chickens. Genome-wide mapping of pooled heterozygosity highlight regions that may be involved in adaptation to the feral environment. The expression QTL results bring us closer to knowledge about the molecular basis of domestication traits in the chicken, suggesting plausible candidate genes and opening up for functional studies of individual loci. The population genomic study shows that feralisation has a mostly different genomic architecture than domestication, and suggests phenotypic effects, based on overlap with domestication QTL regions, for some of the identified regions.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2015. 28 p.
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1708
National Category
urn:nbn:se:liu:diva-122280 (URN)10.3384/diss.diva-122280 (DOI)978-91-7685-932-2 (Print) (ISBN)
Public defence
2015-12-18, Planck, Fysikhuset, Campus Valla, Linköping, 10:15 (English)
Available from: 2015-11-02 Created: 2015-10-27 Last updated: 2015-11-05Bibliographically approved

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