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The prognostic significance of peroxisome proliferator-activated receptor beta expression in the vascular endothelial cells of colorectal cancer
Sichuan University, Peoples R China Sichuan University, Peoples R China .
Sichuan University, Peoples R China Sichuan University, Peoples R China .
Sichuan University, Peoples R China Sichuan University, Peoples R China .
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Norrköping.
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2014 (English)In: Journal of gastroenterology, ISSN 0944-1174, E-ISSN 1435-5922, Vol. 49, no 3, 436-445 p.Article in journal (Refereed) Published
Abstract [en]

Currently, little is known regarding the role of peroxisome proliferator-activated receptor-beta (PPAR beta) in the vascular endothelial cells (VECs) of colorectal cancers (CRCs). The aim of this study was to investigate the relationship of PPAR beta expression in the VECs of CRCs in terms of the prognosis and clinicopathological features of CRC patients. The expression and localization of PPAR beta in the primary cancers and the matched normal mucosal samples of 141 Swedish CRC patients were analyzed in terms of its correlation with clinicopathological features and the expression of angiogenesis-related genes. This study also included 92 Chinese CRC patients. PPAR beta was predominantly localized in the cytoplasm and was significantly downregulated in the VECs of CRC compared to that of the normal mucosa. The low expression levels of PPAR beta in the VECs of CRC were statistically correlated with enhanced differentiation, early staging and favorable overall survival and were associated with the increased expression of VEGF and D2-40. The patients exhibiting elevated expression of PPAR beta in CRC cells but reduced expression in VECs exhibited more favorable survival compared with the other patients, whereas the patients with reduced expression of PPAR beta in CRC cells but increased expression in VECs exhibited less favorable prognosis. PPAR beta might play a tumor suppressor role in CRC cells in contrast to a tumor promoter role in the VECs of CRCs.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2014. Vol. 49, no 3, 436-445 p.
Keyword [en]
Peroxisome proliferator-activated receptor-beta; Colorectal cancer; Prognosis; Vascular endothelial cells; Angiogenesis
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-106030DOI: 10.1007/s00535-013-0845-7ISI: 000333056700007OAI: oai:DiVA.org:liu-106030DiVA: diva2:712931
Available from: 2014-04-17 Created: 2014-04-17 Last updated: 2017-12-05

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Arbman, GunnarSun, Xiao-Feng

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Division of Clinical SciencesFaculty of Health SciencesDepartment of Surgery in NorrköpingDepartment of Oncology
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