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Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity
Ryhov County Hospital, Sweden .
Karolinska Institute, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Ryhov County Hospital, Sweden .
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2014 (English)In: Age (Omaha), ISSN 0161-9152, E-ISSN 1574-4647, Vol. 36, no 2, 571-582 p.Article in journal (Refereed) Published
Abstract [en]

Cytomegalovirus (CMV) infection induces profound changes in different subsets of the cellular immune system. We have previously identified an immune risk profile (IRP) where CMV-associated changes in the T cell compartment, defined as a CD4/CD8 ratio less than 1, are associated with increased mortality in elderly people. Since natural killer (NK) cells have an important role in the defense against viral infections, we examined whether the expansion of CD8 + T cells seen in individuals with CD4/CD8 ratio less than 1 is coupled to a parallel skewing of the NK cell compartment. A number of 151 subjects were examined with CMV serology and a flow cytometry panel for assessment of T cell and NK cell subsets. CMV-seropositive individuals had higher frequencies of CD57 + and NKG2C + NK cells and lower frequencies of NKG2A + NK cells, in line with a more differentiated NK cell compartment. Intriguingly, however, there was no correlation between CD4/CD8 ratio and NK cell repertoires among CMV-seropositive donors, despite the profound skewing of the T cell compartment in the group with CD4/CD8 ratio less than 1. Conversely, donors with profound expansion of NK cells, defined as NKG2C + NK cells with high expression of CD57 and ILT-2, did not display more common changes in their T cell repertoire, suggesting that NK cell expansion is independent of the T cell-defined IRP. Altogether, these results indicate that the effect of CMV on CD8 T cells and NK cells is largely nonoverlapping and independent.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2014. Vol. 36, no 2, 571-582 p.
Keyword [en]
Cytomegalovirus; Immunosenescence; Immune risk profile; Natural killer cells
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-106122DOI: 10.1007/s11357-013-9587-yISI: 000333048600007OAI: diva2:714044
Available from: 2014-04-25 Created: 2014-04-24 Last updated: 2014-04-25

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Ernerudh, Jan
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Division of Inflammation MedicineFaculty of Health SciencesDepartment of Clinical Immunology and Transfusion Medicine
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